cpna-3
C. elegans
VWFA domain-containing protein
What the model saw
Gene: cpna-3 Organism: Caenorhabditis elegans Known functions: VWFA domain-containing protein. calcium-dependent phospholipid binding.
View unredacted entry
VWFA domain-containing protein. calcium-dependent phospholipid binding.
Solver output
cpna-3 encodes a VWFA (von Willebrand Factor A) domain-containing protein with calcium-dependent phospholipid binding activity. VWFA domains are typically involved in protein-protein interactions and extracellular matrix adhesion, while calcium-dependent phospholipid binding is characteristic of annexin-like proteins involved in membrane dynamics and signaling. Neither function maps cleanly to a well-established pro- or anti-longevity pathway in C. elegans. Calcium signaling can intersect with multiple aging hallmarks (mitochondrial function, proteostasis, intercellular communication), but the specific molecular role of cpna-3 in any longevity-relevant pathway is not well-defined by these annotations alone. Without evidence linking this gene to insulin/IGF-1, TOR, mitochondrial, or other canonical aging pathways in C. elegans, a directional prediction cannot be confidently made.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" with low confidence (0.3), while the ground truth is "anti_longevity." The model's reasoning is plausible given the limited functional information provided (VWFA domain, calcium-dependent phospholipid binding), but it failed to make a directional prediction. The model correctly identified that these functions don't map cleanly to canonical longevity pathways, but this is a case where the model should have attempted a directional guess rather than defaulting to "unclear." The mechanistic reasoning is generic and doesn't identify any specific anti-longevity mechanism. The model's uncertainty is somewhat appropriate given the sparse annotation, but the ground truth is definitively anti_longevity, making this a missed prediction.
Raw API responses
solver
{
"reasoning": "cpna-3 encodes a VWFA (von Willebrand Factor A) domain-containing protein with calcium-dependent phospholipid binding activity. VWFA domains are typically involved in protein-protein interactions and extracellular matrix adhesion, while calcium-dependent phospholipid binding is characteristic of annexin-like proteins involved in membrane dynamics and signaling. Neither function maps cleanly to a well-established pro- or anti-longevity pathway in C. elegans. Calcium signaling can intersect with multiple aging hallmarks (mitochondrial function, proteostasis, intercellular communication), but the specific molecular role of cpna-3 in any longevity-relevant pathway is not well-defined by these annotations alone. Without evidence linking this gene to insulin/IGF-1, TOR, mitochondrial, or other canonical aging pathways in C. elegans, a directional prediction cannot be confidently made.",
"confidence": 0.3,
"key_pathways": [
"calcium-dependent phospholipid binding",
"VWFA domain-mediated protein interactions",
"membrane dynamics"
],
"mechanism_class": "unclear",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" with low confidence (0.3), while the ground truth is \"anti_longevity.\" The model's reasoning is plausible given the limited functional information provided (VWFA domain, calcium-dependent phospholipid binding), but it failed to make a directional prediction. The model correctly identified that these functions don't map cleanly to canonical longevity pathways, but this is a case where the model should have attempted a directional guess rather than defaulting to \"unclear.\" The mechanistic reasoning is generic and doesn't identify any specific anti-longevity mechanism. The model's uncertainty is somewhat appropriate given the sparse annotation, but the ground truth is definitively anti_longevity, making this a missed prediction.",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}