cpn-3
C. elegans
Calponin-homology (CH) domain-containing protein
What the model saw
Gene: cpn-3 Organism: Caenorhabditis elegans Known functions: Calponin-homology (CH) domain-containing protein. actin filament binding.
View unredacted entry
Calponin-homology (CH) domain-containing protein. actin filament binding.
Solver output
CPN-3 is a calponin-homology (CH) domain-containing protein with actin filament binding activity. Calponin-family proteins typically regulate actin cytoskeleton dynamics, which can influence muscle function, cell motility, and mechanosensing. While actin cytoskeletal integrity is important for organismal health and has been linked to aging contexts (e.g., muscle sarcomere maintenance in C. elegans), the specific role of cpn-3 in longevity pathways is not clearly established from these annotations alone. CH domain proteins can act as scaffolds or regulators of actin-associated signaling, but without evidence linking cpn-3 specifically to known longevity pathways (e.g., IIS, TOR, mitochondrial function), a directional prediction is not well-supported. The function is too general to confidently assign a pro- or anti-longevity role.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" with low confidence (0.35), while the ground truth is "anti_longevity." The model's reasoning about calponin-homology domain proteins and actin cytoskeleton regulation is plausible but generic, and it correctly identifies that it lacks specific evidence to make a directional call. However, the ground truth indicates cpn-3 is anti-longevity, meaning its loss likely extends lifespan. The model failed to commit to any directional prediction. The reasoning quality is modest — it correctly identifies relevant biology but doesn't leverage any specific knowledge about cpn-3's role in aging. This is a case of appropriate uncertainty given limited information, but the model still got the answer wrong.
Raw API responses
solver
{
"reasoning": "CPN-3 is a calponin-homology (CH) domain-containing protein with actin filament binding activity. Calponin-family proteins typically regulate actin cytoskeleton dynamics, which can influence muscle function, cell motility, and mechanosensing. While actin cytoskeletal integrity is important for organismal health and has been linked to aging contexts (e.g., muscle sarcomere maintenance in C. elegans), the specific role of cpn-3 in longevity pathways is not clearly established from these annotations alone. CH domain proteins can act as scaffolds or regulators of actin-associated signaling, but without evidence linking cpn-3 specifically to known longevity pathways (e.g., IIS, TOR, mitochondrial function), a directional prediction is not well-supported. The function is too general to confidently assign a pro- or anti-longevity role.",
"confidence": 0.35,
"key_pathways": [
"actin cytoskeleton regulation",
"calponin-homology domain signaling",
"muscle cytoskeletal integrity"
],
"mechanism_class": "unclear",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" with low confidence (0.35), while the ground truth is \"anti_longevity.\" The model's reasoning about calponin-homology domain proteins and actin cytoskeleton regulation is plausible but generic, and it correctly identifies that it lacks specific evidence to make a directional call. However, the ground truth indicates cpn-3 is anti-longevity, meaning its loss likely extends lifespan. The model failed to commit to any directional prediction. The reasoning quality is modest — it correctly identifies relevant biology but doesn't leverage any specific knowledge about cpn-3's role in aging. This is a case of appropriate uncertainty given limited information, but the model still got the answer wrong.",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}