t05a1.5
C. elegans
Major facilitator superfamily (MFS) profile domain-containing protein
What the model saw
Gene: T05A1.5 Organism: Caenorhabditis elegans Known functions: Major facilitator superfamily (MFS) profile domain-containing protein. transmembrane transporter activity.
View unredacted entry
Major facilitator superfamily (MFS) profile domain-containing protein. transmembrane transporter activity.
Solver output
T05A1.5 encodes a Major Facilitator Superfamily (MFS) transmembrane transporter in C. elegans. MFS transporters are a large and diverse superfamily that can transport a wide variety of substrates including sugars, amino acids, ions, drugs, and metabolites. Without knowledge of the specific substrate transported, it is not possible to confidently assign a pro- or anti-longevity role. Depending on the substrate, this transporter could influence nutrient sensing, metabolic homeostasis, or xenobiotic clearance — pathways with opposing effects on longevity. The functional annotation is too substrate-agnostic to support a directional prediction.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" with low confidence (0.3), while the ground truth is "anti_longevity." The model's reasoning is logically sound given the limited information provided — MFS transporters are indeed a diverse superfamily and without substrate specificity, directionality is genuinely hard to predict. However, the model failed to make the correct directional call. The reasoning quality is decent (acknowledges the ambiguity appropriately), but the prediction is wrong. This is a case of appropriate uncertainty rather than confident wrongness, but the answer is still incorrect.
Raw API responses
solver
{
"reasoning": "T05A1.5 encodes a Major Facilitator Superfamily (MFS) transmembrane transporter in C. elegans. MFS transporters are a large and diverse superfamily that can transport a wide variety of substrates including sugars, amino acids, ions, drugs, and metabolites. Without knowledge of the specific substrate transported, it is not possible to confidently assign a pro- or anti-longevity role. Depending on the substrate, this transporter could influence nutrient sensing, metabolic homeostasis, or xenobiotic clearance — pathways with opposing effects on longevity. The functional annotation is too substrate-agnostic to support a directional prediction.",
"confidence": 0.3,
"key_pathways": [
"MFS transmembrane transport",
"nutrient/metabolite homeostasis",
"deregulated nutrient sensing"
],
"mechanism_class": "unclear",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" with low confidence (0.3), while the ground truth is \"anti_longevity.\" The model's reasoning is logically sound given the limited information provided — MFS transporters are indeed a diverse superfamily and without substrate specificity, directionality is genuinely hard to predict. However, the model failed to make the correct directional call. The reasoning quality is decent (acknowledges the ambiguity appropriately), but the prediction is wrong. This is a case of appropriate uncertainty rather than confident wrongness, but the answer is still incorrect.",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 3,
"ground_truth_questionable": false
}