f09f7.5
C. elegans
CRIB domain-containing protein
What the model saw
Gene: F09F7.5 Organism: Caenorhabditis elegans Known functions: CRIB domain-containing protein. protein binding. small GTPase binding.
View unredacted entry
CRIB domain-containing protein. protein binding. small GTPase binding.
Solver output
F09F7.5 contains a CRIB (Cdc42/Rac Interactive Binding) domain, which mediates binding to active (GTP-bound) small GTPases such as Cdc42 and Rac1. CRIB domain proteins typically function as effectors or scaffolds downstream of Rho-family GTPases, which regulate cytoskeletal dynamics, cell polarity, and intracellular signaling. While Rho GTPase signaling can intersect with longevity-relevant pathways (e.g., insulin/IGF-1 signaling, stress responses), the specific role of this uncharacterized CRIB protein in C. elegans aging is not determinable from these annotations alone. The molecular function annotations are too generic — protein binding and small GTPase binding — to confidently assign a pro- or anti-longevity role without knowing which downstream effector cascade this protein modulates.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" while the ground truth is "anti_longevity." The model's reasoning is logically sound given the limited information provided — a CRIB domain protein with only generic annotations (protein binding, small GTPase binding) genuinely doesn't provide strong directional evidence for longevity influence. The model appropriately acknowledged uncertainty rather than guessing. However, the answer is still wrong. The mechanism class of "altered_intercellular_communication" seems somewhat speculative and not well-supported by the annotations. The reasoning quality is decent in that it correctly identifies the CRIB domain function and its downstream signaling context, but fails to arrive at the correct answer. This is a case of appropriate uncertainty rather than confident wrongness.
Raw API responses
solver
{
"reasoning": "F09F7.5 contains a CRIB (Cdc42/Rac Interactive Binding) domain, which mediates binding to active (GTP-bound) small GTPases such as Cdc42 and Rac1. CRIB domain proteins typically function as effectors or scaffolds downstream of Rho-family GTPases, which regulate cytoskeletal dynamics, cell polarity, and intracellular signaling. While Rho GTPase signaling can intersect with longevity-relevant pathways (e.g., insulin/IGF-1 signaling, stress responses), the specific role of this uncharacterized CRIB protein in C. elegans aging is not determinable from these annotations alone. The molecular function annotations are too generic — protein binding and small GTPase binding — to confidently assign a pro- or anti-longevity role without knowing which downstream effector cascade this protein modulates.",
"confidence": 0.35,
"key_pathways": [
"Rho/Cdc42 GTPase signaling",
"cytoskeletal regulation",
"cell polarity signaling"
],
"mechanism_class": "altered_intercellular_communication",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" while the ground truth is \"anti_longevity.\" The model's reasoning is logically sound given the limited information provided — a CRIB domain protein with only generic annotations (protein binding, small GTPase binding) genuinely doesn't provide strong directional evidence for longevity influence. The model appropriately acknowledged uncertainty rather than guessing. However, the answer is still wrong. The mechanism class of \"altered_intercellular_communication\" seems somewhat speculative and not well-supported by the annotations. The reasoning quality is decent in that it correctly identifies the CRIB domain function and its downstream signaling context, but fails to arrive at the correct answer. This is a case of appropriate uncertainty rather than confident wrongness.",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 3,
"ground_truth_questionable": false
}