FAR8
S. cerevisiae
Far8p
What the model saw
Gene: FAR8 Organism: Saccharomyces cerevisiae Known functions: Far8p. protein binding. protein-macromolecule adaptor activity.
View unredacted entry
Far8p. protein binding. protein-macromolecule adaptor activity.
Solver output
FAR8 (Factor ARrest 8) is a component of the FAR complex in S. cerevisiae, which is involved in cell cycle arrest in response to pheromone signaling. Its annotated molecular functions — protein binding and protein-macromolecule adaptor activity — indicate it acts as a scaffolding/adaptor protein within this complex. While the FAR complex has been linked to TOR pathway regulation and STRIPAK-like complexes that modulate cell growth and stress responses, the direct connection of FAR8's adaptor role to pro- or anti-longevity outcomes is not clearly established from these annotations alone. The adaptor function could either facilitate growth-promoting signals (anti-longevity) or stress-response coordination (pro-longevity), making a definitive directional prediction difficult without more specific pathway context.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" while the ground truth is "anti_longevity." The model correctly identified FAR8's role in the FAR complex and STRIPAK-like complexes, and even mentioned that its adaptor function "could facilitate growth-promoting signals (anti-longevity)" — so it touched on the correct direction but ultimately declined to commit. The model's reasoning about the FAR complex and TOR pathway modulation is partially relevant, but it failed to make the correct directional call. The confidence was appropriately low (0.35), reflecting genuine uncertainty, but the answer is still wrong. The mechanism reasoning was incomplete — it didn't clearly articulate why FAR8 would be anti-longevity (e.g., deletion of FAR8 extends lifespan, suggesting it normally suppresses longevity).
Raw API responses
solver
{
"reasoning": "FAR8 (Factor ARrest 8) is a component of the FAR complex in S. cerevisiae, which is involved in cell cycle arrest in response to pheromone signaling. Its annotated molecular functions — protein binding and protein-macromolecule adaptor activity — indicate it acts as a scaffolding/adaptor protein within this complex. While the FAR complex has been linked to TOR pathway regulation and STRIPAK-like complexes that modulate cell growth and stress responses, the direct connection of FAR8's adaptor role to pro- or anti-longevity outcomes is not clearly established from these annotations alone. The adaptor function could either facilitate growth-promoting signals (anti-longevity) or stress-response coordination (pro-longevity), making a definitive directional prediction difficult without more specific pathway context.",
"confidence": 0.35,
"key_pathways": [
"FAR complex / pheromone-induced cell cycle arrest",
"STRIPAK-like complex signaling",
"TOR pathway modulation"
],
"mechanism_class": "cellular_senescence",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" while the ground truth is \"anti_longevity.\" The model correctly identified FAR8's role in the FAR complex and STRIPAK-like complexes, and even mentioned that its adaptor function \"could facilitate growth-promoting signals (anti-longevity)\" — so it touched on the correct direction but ultimately declined to commit. The model's reasoning about the FAR complex and TOR pathway modulation is partially relevant, but it failed to make the correct directional call. The confidence was appropriately low (0.35), reflecting genuine uncertainty, but the answer is still wrong. The mechanism reasoning was incomplete — it didn't clearly articulate why FAR8 would be anti-longevity (e.g., deletion of FAR8 extends lifespan, suggesting it normally suppresses longevity).",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}