odr-2
C. elegans
Homolog of Odr-2 (Two);Protein quiver;Protein sleepless
What the model saw
Gene: odr-2 Organism: Caenorhabditis elegans Known functions: Homolog of Odr-2 (Two);Protein quiver;Protein sleepless.
View unredacted entry
Homolog of Odr-2 (Two);Protein quiver;Protein sleepless.
Solver output
odr-2 in C. elegans is a member of the Ly6/uPAR superfamily, related to Drosophila proteins Quiver and Sleepless. Sleepless is a GPI-anchored protein that modulates potassium channel activity (Shaker/Kv channels) and regulates sleep/wake behavior and neuronal excitability. In C. elegans, odr-2 is expressed in chemosensory neurons and modulates olfactory signaling, but its precise role in longevity pathways is not well established. While neuronal signaling from sensory neurons (particularly AWA/AWC) can influence lifespan via insulin/IGF-1 signaling, the specific contribution of odr-2 as a Ly6-family modulator of ion channels or neuronal excitability does not map cleanly to a pro- or anti-longevity function without direct experimental evidence linking it to lifespan regulation.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" with low confidence (0.35), while the ground truth is "anti_longevity." The model correctly identified odr-2 as a Ly6/uPAR family member related to Sleepless/Quiver and noted its role in chemosensory neurons, but failed to commit to a longevity direction. The mechanistic reasoning about potassium channel modulation and chemosensory neuron-mediated insulin/IGF-1 signaling is plausible but speculative and not directly tied to the anti-longevity classification. The model appropriately acknowledged uncertainty but ultimately gave the wrong answer. The reasoning quality is modest — it shows domain knowledge but doesn't leverage it to reach the correct conclusion.
Raw API responses
solver
{
"reasoning": "odr-2 in C. elegans is a member of the Ly6/uPAR superfamily, related to Drosophila proteins Quiver and Sleepless. Sleepless is a GPI-anchored protein that modulates potassium channel activity (Shaker/Kv channels) and regulates sleep/wake behavior and neuronal excitability. In C. elegans, odr-2 is expressed in chemosensory neurons and modulates olfactory signaling, but its precise role in longevity pathways is not well established. While neuronal signaling from sensory neurons (particularly AWA/AWC) can influence lifespan via insulin/IGF-1 signaling, the specific contribution of odr-2 as a Ly6-family modulator of ion channels or neuronal excitability does not map cleanly to a pro- or anti-longevity function without direct experimental evidence linking it to lifespan regulation.",
"confidence": 0.35,
"key_pathways": [
"Ly6/uPAR neuronal signaling",
"potassium channel modulation (Shaker/Kv)",
"chemosensory neuron-mediated insulin/IGF-1 signaling"
],
"mechanism_class": "altered_intercellular_communication",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" with low confidence (0.35), while the ground truth is \"anti_longevity.\" The model correctly identified odr-2 as a Ly6/uPAR family member related to Sleepless/Quiver and noted its role in chemosensory neurons, but failed to commit to a longevity direction. The mechanistic reasoning about potassium channel modulation and chemosensory neuron-mediated insulin/IGF-1 signaling is plausible but speculative and not directly tied to the anti-longevity classification. The model appropriately acknowledged uncertainty but ultimately gave the wrong answer. The reasoning quality is modest — it shows domain knowledge but doesn't leverage it to reach the correct conclusion.",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}