rpl-10L
C. elegans
Large ribosomal subunit protein uL16
What the model saw
Gene: rpl-10L Organism: Caenorhabditis elegans Known functions: Large ribosomal subunit protein uL16. structural constituent of ribosome.
View unredacted entry
Large ribosomal subunit protein uL16. structural constituent of ribosome.
Solver output
rpl-10L encodes the large ribosomal subunit protein uL16, a core structural component of the 60S ribosomal subunit required for mRNA translation. Ribosomal protein levels are tightly coupled to TOR (Target of Rapamycin) signaling, the master nutrient-sensing pathway: high TOR activity upregulates ribosome biogenesis and global translation, which is associated with accelerated aging, while reduced ribosomal activity extends lifespan. In C. elegans, partial loss-of-function of multiple large ribosomal subunit proteins (e.g., rpl-5, rpl-11) has been shown to extend lifespan via reduced translation rates and activation of stress-response pathways. As a structural constituent of the ribosome, rpl-10L's normal function sustains high translational capacity, which promotes growth and reproduction at the cost of longevity. Reduction of ribosomal protein function also intersects with the IIS/DAF-16 and germline signaling pathways to modulate lifespan in worms.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted anti_longevity for rpl-10L. The mechanistic reasoning is sound: ribosomal proteins like rpl-10L support high translational capacity, and their reduction (loss-of-function) extends lifespan in C. elegans, making the normal function anti-longevity. The model correctly cites analogous ribosomal proteins (rpl-5, rpl-11) and correctly links ribosome function to TOR/nutrient sensing. The mechanism class "deregulated_nutrient_sensing" is a reasonable but slightly imprecise label — "translation/ribosome biogenesis" would be more direct, though TOR signaling is closely related. Overall, the reasoning is well-grounded and the answer is correct.
Raw API responses
solver
{
"reasoning": "rpl-10L encodes the large ribosomal subunit protein uL16, a core structural component of the 60S ribosomal subunit required for mRNA translation. Ribosomal protein levels are tightly coupled to TOR (Target of Rapamycin) signaling, the master nutrient-sensing pathway: high TOR activity upregulates ribosome biogenesis and global translation, which is associated with accelerated aging, while reduced ribosomal activity extends lifespan. In C. elegans, partial loss-of-function of multiple large ribosomal subunit proteins (e.g., rpl-5, rpl-11) has been shown to extend lifespan via reduced translation rates and activation of stress-response pathways. As a structural constituent of the ribosome, rpl-10L's normal function sustains high translational capacity, which promotes growth and reproduction at the cost of longevity. Reduction of ribosomal protein function also intersects with the IIS/DAF-16 and germline signaling pathways to modulate lifespan in worms.",
"confidence": 0.72,
"key_pathways": [
"TOR/ribosome biogenesis signaling",
"global mRNA translation regulation",
"IIS/DAF-16 longevity pathway"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "anti_longevity"
}advisor
{
"notes": "The model correctly predicted anti_longevity for rpl-10L. The mechanistic reasoning is sound: ribosomal proteins like rpl-10L support high translational capacity, and their reduction (loss-of-function) extends lifespan in C. elegans, making the normal function anti-longevity. The model correctly cites analogous ribosomal proteins (rpl-5, rpl-11) and correctly links ribosome function to TOR/nutrient sensing. The mechanism class \"deregulated_nutrient_sensing\" is a reasonable but slightly imprecise label — \"translation/ribosome biogenesis\" would be more direct, though TOR signaling is closely related. Overall, the reasoning is well-grounded and the answer is correct.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 4,
"ground_truth_questionable": false
}