rpl-10a
C. elegans
Large ribosomal subunit protein uL1
What the model saw
Gene: rpl-10a Organism: Caenorhabditis elegans Known functions: Large ribosomal subunit protein uL1. RNA binding. structural constituent of ribosome.
View unredacted entry
Large ribosomal subunit protein uL1. RNA binding. structural constituent of ribosome.
Solver output
rpl-10a encodes the large ribosomal subunit protein uL1, a core structural component of the 60S ribosomal subunit required for mRNA translation. Ribosomal protein genes in C. elegans are well-established modulators of longevity: partial loss-of-function of large subunit ribosomal proteins (e.g., rpl-4, rpl-11, rpl-25) consistently extends lifespan by reducing global translational capacity, which mimics dietary restriction and downregulates TOR/TORC1 signaling. The normal function of rpl-10a is to sustain high translational output, which promotes anabolic growth but accelerates aging. Reduced ribosome activity also activates stress-response pathways and proteostasis networks that are pro-longevity. Therefore, the wild-type (full) activity of rpl-10a opposes longevity by maintaining elevated protein synthesis rates downstream of nutrient-sensing/TOR signaling.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted anti_longevity for rpl-10a. The mechanistic reasoning is sound: ribosomal protein genes in C. elegans are well-known anti-longevity factors because their knockdown reduces translational output, mimicking dietary restriction and extending lifespan. The model correctly identifies that wild-type rpl-10a activity promotes aging by sustaining high protein synthesis. The mechanism class "deregulated_nutrient_sensing" is a reasonable (if slightly imprecise) categorization — the more direct mechanism is translational regulation/ribosome function, but TOR/nutrient sensing is closely linked. The reasoning is well-supported by the literature on ribosomal protein RNAi in C. elegans. Confidence of 0.72 is appropriate given the general pattern of ribosomal proteins in this organism.
Raw API responses
solver
{
"reasoning": "rpl-10a encodes the large ribosomal subunit protein uL1, a core structural component of the 60S ribosomal subunit required for mRNA translation. Ribosomal protein genes in C. elegans are well-established modulators of longevity: partial loss-of-function of large subunit ribosomal proteins (e.g., rpl-4, rpl-11, rpl-25) consistently extends lifespan by reducing global translational capacity, which mimics dietary restriction and downregulates TOR/TORC1 signaling. The normal function of rpl-10a is to sustain high translational output, which promotes anabolic growth but accelerates aging. Reduced ribosome activity also activates stress-response pathways and proteostasis networks that are pro-longevity. Therefore, the wild-type (full) activity of rpl-10a opposes longevity by maintaining elevated protein synthesis rates downstream of nutrient-sensing/TOR signaling.",
"confidence": 0.72,
"key_pathways": [
"TOR/TORC1 nutrient sensing",
"ribosome biogenesis and translational regulation",
"dietary restriction mimicry via reduced protein synthesis"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "anti_longevity"
}advisor
{
"notes": "The model correctly predicted anti_longevity for rpl-10a. The mechanistic reasoning is sound: ribosomal protein genes in C. elegans are well-known anti-longevity factors because their knockdown reduces translational output, mimicking dietary restriction and extending lifespan. The model correctly identifies that wild-type rpl-10a activity promotes aging by sustaining high protein synthesis. The mechanism class \"deregulated_nutrient_sensing\" is a reasonable (if slightly imprecise) categorization — the more direct mechanism is translational regulation/ribosome function, but TOR/nutrient sensing is closely linked. The reasoning is well-supported by the literature on ribosomal protein RNAi in C. elegans. Confidence of 0.72 is appropriate given the general pattern of ribosomal proteins in this organism.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 4,
"ground_truth_questionable": false
}