MUB1
S. cerevisiae
MYND-type zinc finger protein MUB1
What the model saw
Gene: MUB1 Organism: Saccharomyces cerevisiae Known functions: MYND-type zinc finger protein MUB1. protein binding. zinc ion binding.
View unredacted entry
MYND-type zinc finger protein MUB1. protein binding. zinc ion binding.
Solver output
MUB1 encodes a MYND-type zinc finger protein in S. cerevisiae, with annotated functions limited to protein binding and zinc ion binding. MYND-type zinc finger domains typically mediate protein-protein interactions, often serving as adaptor or scaffold proteins in transcriptional regulation or ubiquitin-proteasome pathways (MUB1 is known to interact with the ubiquitin ligase Ubr2). However, the available molecular function annotations are too general to confidently assign a pro- or anti-longevity role, as protein binding and zinc ion binding are broad activities that do not pinpoint a specific aging-relevant pathway. Without more specific functional context—such as confirmed roles in proteostasis, nutrient sensing, or stress response—a directional prediction cannot be reliably made.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" with low confidence (0.35), while the ground truth is "anti_longevity." The model did correctly identify MUB1's interaction with Ubr2 (a ubiquitin ligase), which is relevant to its anti-longevity role, but failed to leverage this to make a directional prediction. MUB1 is known to function as an adaptor for the Ubr2 ubiquitin ligase, and deletion of MUB1 extends lifespan in yeast, making it anti-longevity. The model's reasoning was overly cautious given that it actually identified the key mechanistic clue (Ubr2 interaction in the ubiquitin-proteasome system). A more informed prediction could have been made based on the known role of ubiquitin-proteasome pathway components in aging. The model appropriately expressed uncertainty but missed an opportunity to make a more informed directional guess.
Raw API responses
solver
{
"reasoning": "MUB1 encodes a MYND-type zinc finger protein in S. cerevisiae, with annotated functions limited to protein binding and zinc ion binding. MYND-type zinc finger domains typically mediate protein-protein interactions, often serving as adaptor or scaffold proteins in transcriptional regulation or ubiquitin-proteasome pathways (MUB1 is known to interact with the ubiquitin ligase Ubr2). However, the available molecular function annotations are too general to confidently assign a pro- or anti-longevity role, as protein binding and zinc ion binding are broad activities that do not pinpoint a specific aging-relevant pathway. Without more specific functional context—such as confirmed roles in proteostasis, nutrient sensing, or stress response—a directional prediction cannot be reliably made.",
"confidence": 0.35,
"key_pathways": [
"MYND-type zinc finger protein-protein interaction",
"ubiquitin-proteasome system (Ubr2 interaction)",
"transcriptional regulation"
],
"mechanism_class": "unclear",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" with low confidence (0.35), while the ground truth is \"anti_longevity.\" The model did correctly identify MUB1's interaction with Ubr2 (a ubiquitin ligase), which is relevant to its anti-longevity role, but failed to leverage this to make a directional prediction. MUB1 is known to function as an adaptor for the Ubr2 ubiquitin ligase, and deletion of MUB1 extends lifespan in yeast, making it anti-longevity. The model's reasoning was overly cautious given that it actually identified the key mechanistic clue (Ubr2 interaction in the ubiquitin-proteasome system). A more informed prediction could have been made based on the known role of ubiquitin-proteasome pathway components in aging. The model appropriately expressed uncertainty but missed an opportunity to make a more informed directional guess.",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}