par1
S. pombe
serine/threonine protein phosphatase PP2A regulatory subunit B-56 Par1
What the model saw
Gene: par1 Organism: Schizosaccharomyces pombe Known functions: serine/threonine protein phosphatase PP2A regulatory subunit B-56 Par1. protein binding. protein phosphatase activator activity. protein phosphatase regulator activity. protein-macromolecule adaptor activity.
View unredacted entry
serine/threonine protein phosphatase PP2A regulatory subunit B-56 Par1. protein binding. protein phosphatase activator activity. protein phosphatase regulator activity. protein-macromolecule adaptor activity.
Solver output
Par1 is a B56 regulatory subunit of PP2A (Protein Phosphatase 2A), a major serine/threonine phosphatase complex. PP2A-B56 complexes are well-established regulators of cell cycle progression, DNA damage response, and chromatin-associated processes. By directing PP2A catalytic activity to specific substrates, Par1/B56 promotes dephosphorylation of key targets involved in genome integrity and epigenetic regulation. PP2A activity broadly counteracts oncogenic kinase signaling (e.g., opposing Akt/TOR pathway hyperactivation) and supports proper chromosome segregation, both of which are pro-longevity functions. In fission yeast, PP2A-B56 subunits also regulate mitotic exit and stress response pathways, and loss of PP2A regulatory function is associated with accelerated cellular aging phenotypes. The protein-macromolecule adaptor and phosphatase activator roles indicate Par1 fine-tunes phosphorylation states that maintain cellular homeostasis, consistent with a pro-longevity role.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted pro_longevity but the ground truth is anti_longevity. The model's reasoning about PP2A-B56 being generally pro-longevity is plausible in a general context, but it fails to account for the specific role of par1 in S. pombe where it acts as an anti-longevity factor. The model made a reasonable mechanistic argument but drew the wrong conclusion. The mechanism class of "epigenetic_alterations" is also questionable for a phosphatase regulatory subunit whose primary roles are in cell cycle and signaling regulation. The model showed moderate confidence (0.65) in the wrong direction.
Raw API responses
solver
{
"reasoning": "Par1 is a B56 regulatory subunit of PP2A (Protein Phosphatase 2A), a major serine/threonine phosphatase complex. PP2A-B56 complexes are well-established regulators of cell cycle progression, DNA damage response, and chromatin-associated processes. By directing PP2A catalytic activity to specific substrates, Par1/B56 promotes dephosphorylation of key targets involved in genome integrity and epigenetic regulation. PP2A activity broadly counteracts oncogenic kinase signaling (e.g., opposing Akt/TOR pathway hyperactivation) and supports proper chromosome segregation, both of which are pro-longevity functions. In fission yeast, PP2A-B56 subunits also regulate mitotic exit and stress response pathways, and loss of PP2A regulatory function is associated with accelerated cellular aging phenotypes. The protein-macromolecule adaptor and phosphatase activator roles indicate Par1 fine-tunes phosphorylation states that maintain cellular homeostasis, consistent with a pro-longevity role.",
"confidence": 0.65,
"key_pathways": [
"PP2A-B56 phosphatase complex regulation",
"cell cycle and DNA damage checkpoint signaling",
"TOR/nutrient sensing pathway antagonism"
],
"mechanism_class": "epigenetic_alterations",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model predicted pro_longevity but the ground truth is anti_longevity. The model's reasoning about PP2A-B56 being generally pro-longevity is plausible in a general context, but it fails to account for the specific role of par1 in S. pombe where it acts as an anti-longevity factor. The model made a reasonable mechanistic argument but drew the wrong conclusion. The mechanism class of \"epigenetic_alterations\" is also questionable for a phosphatase regulatory subunit whose primary roles are in cell cycle and signaling regulation. The model showed moderate confidence (0.65) in the wrong direction.",
"failure_mode": "confident_wrong",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}