lin-15B
C. elegans
Protein lin-15B
What the model saw
Gene: lin-15B Organism: Caenorhabditis elegans Known functions: Protein lin-15B. signaling receptor binding.
View unredacted entry
Protein lin-15B. signaling receptor binding.
Solver output
lin-15B in C. elegans is a synthetic multivulva (synMuv) class B gene that encodes a transcriptional repressor functioning as part of the DRM/DREAM complex, which represses germline and somatic gene expression programs. Loss of lin-15B has been shown to extend lifespan in C. elegans by derepressing stress-response and longevity-associated transcriptional programs, suggesting its normal function is to repress pro-longevity gene expression. Its annotation as a signaling receptor binding protein is consistent with its role in modulating transcriptional repressor complexes that interface with signaling pathways. The DREAM complex in C. elegans coordinates chromatin-level silencing, placing lin-15B squarely in the epigenetic alterations hallmark. Because lin-15B's normal activity suppresses longevity-promoting transcription, its wild-type function is anti-longevity, meaning loss-of-function extends lifespan — so the gene itself is anti-longevity.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicts "pro_longevity" as the longevity influence, matching the ground truth. However, the reasoning is internally contradictory and ultimately wrong in its mechanistic conclusion. The model correctly identifies lin-15B as a synMuv B transcriptional repressor in the DRM/DREAM complex, and correctly notes that loss-of-function extends lifespan. But then it contradicts itself: it first says lin-15B's normal function is "anti-longevity" (because loss-of-function extends lifespan), but then outputs "pro_longevity" as the final answer. The GenAge classification of "pro_longevity" for lin-15B is actually consistent with the interpretation that the gene promotes longevity — but the model's own reasoning argues the opposite (that it's anti-longevity). The model arrives at the correct answer despite its reasoning pointing to the opposite conclusion, suggesting the final answer may have been influenced by prior knowledge or a guess rather than the stated reasoning. The mechanism class of "epigenetic_alterations" is plausible but the reasoning is self-contradictory and confused about the directionality of the longevity effect.
Raw API responses
solver
{
"reasoning": "lin-15B in C. elegans is a synthetic multivulva (synMuv) class B gene that encodes a transcriptional repressor functioning as part of the DRM/DREAM complex, which represses germline and somatic gene expression programs. Loss of lin-15B has been shown to extend lifespan in C. elegans by derepressing stress-response and longevity-associated transcriptional programs, suggesting its normal function is to repress pro-longevity gene expression. Its annotation as a signaling receptor binding protein is consistent with its role in modulating transcriptional repressor complexes that interface with signaling pathways. The DREAM complex in C. elegans coordinates chromatin-level silencing, placing lin-15B squarely in the epigenetic alterations hallmark. Because lin-15B's normal activity suppresses longevity-promoting transcription, its wild-type function is anti-longevity, meaning loss-of-function extends lifespan — so the gene itself is anti-longevity.",
"confidence": 0.52,
"key_pathways": [
"DRM/DREAM transcriptional repressor complex",
"synMuv B chromatin silencing",
"signaling receptor-coupled transcriptional regulation"
],
"mechanism_class": "epigenetic_alterations",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model correctly predicts \"pro_longevity\" as the longevity influence, matching the ground truth. However, the reasoning is internally contradictory and ultimately wrong in its mechanistic conclusion. The model correctly identifies lin-15B as a synMuv B transcriptional repressor in the DRM/DREAM complex, and correctly notes that loss-of-function extends lifespan. But then it contradicts itself: it first says lin-15B's normal function is \"anti-longevity\" (because loss-of-function extends lifespan), but then outputs \"pro_longevity\" as the final answer. The GenAge classification of \"pro_longevity\" for lin-15B is actually consistent with the interpretation that the gene promotes longevity — but the model's own reasoning argues the opposite (that it's anti-longevity). The model arrives at the correct answer despite its reasoning pointing to the opposite conclusion, suggesting the final answer may have been influenced by prior knowledge or a guess rather than the stated reasoning. The mechanism class of \"epigenetic_alterations\" is plausible but the reasoning is self-contradictory and confused about the directionality of the longevity effect.",
"failure_mode": "right_answer_wrong_reasoning",
"answer_correct": true,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": true
}