ceh-10
C. elegans
Homeobox protein ceh-10
What the model saw
Gene: ceh-10 Organism: Caenorhabditis elegans Known functions: Homeobox protein ceh-10. DNA binding. DNA-binding transcription activator activity, RNA polymerase II-specific. DNA-binding transcription factor activity. DNA-binding transcription factor activity, RNA polymerase II-specific. RNA polymerase II cis-regulatory region sequence-specific DNA binding. RNA polymerase II transcription regulatory region sequence-specific DNA binding.
View unredacted entry
Homeobox protein ceh-10. DNA binding. DNA-binding transcription activator activity, RNA polymerase II-specific. DNA-binding transcription factor activity. DNA-binding transcription factor activity, RNA polymerase II-specific. RNA polymerase II cis-regulatory region sequence-specific DNA binding. RNA polymerase II transcription regulatory region sequence-specific DNA binding.
Solver output
CEH-10 is a homeodomain transcription factor in C. elegans that is the ortholog of vertebrate CHX10/VSX2 and is closely related to the paired-like homeodomain family. As a transcriptional activator acting through RNA Pol II, CEH-10 regulates neuronal identity and development, particularly in interneuron specification. Homeodomain transcription factors in C. elegans can influence longevity by modulating the expression of downstream targets involved in stress response, metabolism, and neuronal signaling pathways (e.g., insulin/IGF-1 signaling via DAF-16 co-regulators or neuroendocrine outputs). CEH-10 has been implicated in regulating AIY interneuron fate, which is part of the thermosensory circuit that modulates lifespan through neuroendocrine signaling. Transcriptional activators that maintain neuronal identity and circuit integrity tend to support organismal homeostasis and thus promote longevity, though the evidence for CEH-10 specifically is limited and indirect.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted pro_longevity for ceh-10. The reasoning is plausible and touches on relevant biology (AIY interneuron regulation, neuroendocrine signaling, thermosensory circuit). However, the model acknowledges the evidence is "limited and indirect," and the confidence is only 0.52, suggesting the correct answer was reached with some uncertainty. The mechanistic reasoning about AIY interneurons and neuroendocrine longevity signaling is reasonable and consistent with known C. elegans biology. The reasoning quality is moderate - it's not wrong but relies on indirect inference rather than direct experimental evidence about ceh-10's role in longevity.
Raw API responses
solver
{
"reasoning": "CEH-10 is a homeodomain transcription factor in C. elegans that is the ortholog of vertebrate CHX10/VSX2 and is closely related to the paired-like homeodomain family. As a transcriptional activator acting through RNA Pol II, CEH-10 regulates neuronal identity and development, particularly in interneuron specification. Homeodomain transcription factors in C. elegans can influence longevity by modulating the expression of downstream targets involved in stress response, metabolism, and neuronal signaling pathways (e.g., insulin/IGF-1 signaling via DAF-16 co-regulators or neuroendocrine outputs). CEH-10 has been implicated in regulating AIY interneuron fate, which is part of the thermosensory circuit that modulates lifespan through neuroendocrine signaling. Transcriptional activators that maintain neuronal identity and circuit integrity tend to support organismal homeostasis and thus promote longevity, though the evidence for CEH-10 specifically is limited and indirect.",
"confidence": 0.52,
"key_pathways": [
"RNA polymerase II-mediated transcriptional activation",
"homeodomain transcription factor neuronal identity regulation",
"neuroendocrine longevity signaling"
],
"mechanism_class": "other",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model correctly predicted pro_longevity for ceh-10. The reasoning is plausible and touches on relevant biology (AIY interneuron regulation, neuroendocrine signaling, thermosensory circuit). However, the model acknowledges the evidence is \"limited and indirect,\" and the confidence is only 0.52, suggesting the correct answer was reached with some uncertainty. The mechanistic reasoning about AIY interneurons and neuroendocrine longevity signaling is reasonable and consistent with known C. elegans biology. The reasoning quality is moderate - it's not wrong but relies on indirect inference rather than direct experimental evidence about ceh-10's role in longevity.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 3,
"ground_truth_questionable": false
}