acs-7
C. elegans
Acyl-CoA synthetase 7
What the model saw
Gene: acs-7 Organism: Caenorhabditis elegans Known functions: Acyl-CoA synthetase 7. CoA-ligase activity. catalytic activity. ligase activity. medium-chain fatty acid-CoA ligase activity.
View unredacted entry
Acyl-CoA synthetase 7. CoA-ligase activity. catalytic activity. ligase activity. medium-chain fatty acid-CoA ligase activity.
Solver output
ACS-7 is a medium-chain fatty acid-CoA ligase (acyl-CoA synthetase) that activates medium-chain fatty acids by conjugating them to CoA, a critical first step in fatty acid beta-oxidation and lipid metabolism. In C. elegans, efficient fatty acid activation and oxidation are linked to mitochondrial energy metabolism and lipid homeostasis, both of which are tightly coupled to nutrient-sensing pathways such as insulin/IGF-1 signaling and AMPK. Proper channeling of fatty acids into beta-oxidation supports mitochondrial function and reduces lipotoxic lipid accumulation, which is associated with extended lifespan in worms. Loss of acyl-CoA synthetase activity can impair fatty acid catabolism, disrupt energy balance, and promote lipid accumulation—phenotypes associated with shortened lifespan. The role of medium-chain fatty acid activation in maintaining metabolic homeostasis places this gene within the deregulated nutrient-sensing hallmark of aging.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted pro_longevity but the ground truth is anti_longevity. The model reasoned that ACS-7 supports fatty acid beta-oxidation and mitochondrial function, and that loss of ACS-7 would impair these processes and shorten lifespan — implying ACS-7 is pro-longevity. However, the ground truth indicates ACS-7 is anti_longevity, meaning its loss (or reduction) actually extends lifespan. This is the opposite of the model's conclusion. The mechanistic reasoning is also incorrect in direction: if ACS-7 is anti_longevity, then its activity likely promotes aging rather than supporting longevity. The model's confidence of 0.62 is moderate but still clearly wrong. The reasoning quality is low because it led to the wrong conclusion despite being logically structured.
Raw API responses
solver
{
"reasoning": "ACS-7 is a medium-chain fatty acid-CoA ligase (acyl-CoA synthetase) that activates medium-chain fatty acids by conjugating them to CoA, a critical first step in fatty acid beta-oxidation and lipid metabolism. In C. elegans, efficient fatty acid activation and oxidation are linked to mitochondrial energy metabolism and lipid homeostasis, both of which are tightly coupled to nutrient-sensing pathways such as insulin/IGF-1 signaling and AMPK. Proper channeling of fatty acids into beta-oxidation supports mitochondrial function and reduces lipotoxic lipid accumulation, which is associated with extended lifespan in worms. Loss of acyl-CoA synthetase activity can impair fatty acid catabolism, disrupt energy balance, and promote lipid accumulation—phenotypes associated with shortened lifespan. The role of medium-chain fatty acid activation in maintaining metabolic homeostasis places this gene within the deregulated nutrient-sensing hallmark of aging.",
"confidence": 0.62,
"key_pathways": [
"fatty acid beta-oxidation",
"lipid homeostasis / nutrient sensing",
"mitochondrial energy metabolism"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model predicted pro_longevity but the ground truth is anti_longevity. The model reasoned that ACS-7 supports fatty acid beta-oxidation and mitochondrial function, and that loss of ACS-7 would impair these processes and shorten lifespan — implying ACS-7 is pro-longevity. However, the ground truth indicates ACS-7 is anti_longevity, meaning its loss (or reduction) actually extends lifespan. This is the opposite of the model's conclusion. The mechanistic reasoning is also incorrect in direction: if ACS-7 is anti_longevity, then its activity likely promotes aging rather than supporting longevity. The model's confidence of 0.62 is moderate but still clearly wrong. The reasoning quality is low because it led to the wrong conclusion despite being logically structured.",
"failure_mode": "confident_wrong",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}