SNF4Agamma
D. melanogaster
SNF4/AMP-activated protein kinase gamma subunit
What the model saw
Gene: SNF4Agamma Organism: Drosophila melanogaster Known functions: SNF4/AMP-activated protein kinase gamma subunit. AMP binding. protein kinase binding. protein kinase regulator activity.
View unredacted entry
SNF4/AMP-activated protein kinase gamma subunit. AMP binding. protein kinase binding. protein kinase regulator activity.
Solver output
SNF4Agamma encodes the regulatory gamma subunit of AMP-activated protein kinase (AMPK), which acts as the AMP-sensing component of the heterotrimeric AMPK complex. By binding AMP (and ADP) under low-energy conditions, the gamma subunit allosterically activates AMPK and protects it from dephosphorylation, thereby coupling cellular energy status to downstream metabolic reprogramming. Active AMPK suppresses anabolic/growth signaling (including TORC1) and promotes catabolic processes such as autophagy and mitochondrial biogenesis — pathways well-established to extend lifespan in Drosophila and other model organisms. Loss of AMPK activity accelerates aging phenotypes, while enhanced AMPK signaling extends lifespan, placing this gamma regulatory subunit firmly in the pro-longevity category through the nutrient/energy-sensing axis.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted pro_longevity for SNF4Agamma with high confidence (0.82). The mechanistic reasoning is excellent: it accurately describes SNF4Agamma as the regulatory gamma subunit of AMPK, explains its role in AMP binding and allosteric activation of the AMPK complex, and correctly links AMPK activation to lifespan extension through TORC1 suppression, autophagy induction, and mitochondrial biogenesis. The mechanism class of "deregulated_nutrient_sensing" is appropriate. The reasoning is well-grounded in established biology and directly relevant to Drosophila longevity research.
Raw API responses
solver
{
"reasoning": "SNF4Agamma encodes the regulatory gamma subunit of AMP-activated protein kinase (AMPK), which acts as the AMP-sensing component of the heterotrimeric AMPK complex. By binding AMP (and ADP) under low-energy conditions, the gamma subunit allosterically activates AMPK and protects it from dephosphorylation, thereby coupling cellular energy status to downstream metabolic reprogramming. Active AMPK suppresses anabolic/growth signaling (including TORC1) and promotes catabolic processes such as autophagy and mitochondrial biogenesis — pathways well-established to extend lifespan in Drosophila and other model organisms. Loss of AMPK activity accelerates aging phenotypes, while enhanced AMPK signaling extends lifespan, placing this gamma regulatory subunit firmly in the pro-longevity category through the nutrient/energy-sensing axis.",
"confidence": 0.82,
"key_pathways": [
"AMPK energy sensing pathway",
"TOR/mTORC1 suppression",
"autophagy induction"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model correctly predicted pro_longevity for SNF4Agamma with high confidence (0.82). The mechanistic reasoning is excellent: it accurately describes SNF4Agamma as the regulatory gamma subunit of AMPK, explains its role in AMP binding and allosteric activation of the AMPK complex, and correctly links AMPK activation to lifespan extension through TORC1 suppression, autophagy induction, and mitochondrial biogenesis. The mechanism class of \"deregulated_nutrient_sensing\" is appropriate. The reasoning is well-grounded in established biology and directly relevant to Drosophila longevity research.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 5,
"ground_truth_questionable": false
}