ATPsynbetaL
D. melanogaster
ATP synthase, beta subunit-like
What the model saw
Gene: ATPsynbetaL Organism: Drosophila melanogaster Known functions: ATP synthase, beta subunit-like. ATP binding. proton-transporting ATP synthase activity, rotational mechanism.
View unredacted entry
ATP synthase, beta subunit-like. ATP binding. proton-transporting ATP synthase activity, rotational mechanism.
Solver output
ATPsynbetaL encodes a beta subunit-like component of the mitochondrial ATP synthase (Complex V), which catalyzes ATP synthesis via a rotational mechanism driven by the proton gradient across the inner mitochondrial membrane. The beta subunit contains the catalytic nucleotide-binding site where ADP is phosphorylated to ATP, making it central to oxidative phosphorylation efficiency. Proper Complex V function is essential for maintaining mitochondrial membrane potential, efficient energy production, and limiting reactive oxygen species (ROS) generation from upstream complexes. In Drosophila, reduced or dysfunctional ATP synthase activity leads to mitochondrial dysfunction, elevated ROS, and shortened lifespan. Conversely, normal or enhanced Complex V activity supports robust mitochondrial bioenergetics, which is consistently associated with healthy aging and longevity across model organisms.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted pro_longevity but the ground truth is anti_longevity. The model's reasoning assumes that normal/enhanced Complex V activity supports longevity, but the actual finding for ATPsynbetaL in Drosophila is anti-longevity (meaning the gene promotes aging/shortens lifespan, or its overexpression reduces lifespan). The model failed to consider that overexpression of ATP synthase components can be detrimental, or that this particular gene's activity negatively impacts longevity. The reasoning is plausible in general terms but leads to the wrong conclusion with moderate-high confidence (0.72), making this a confident wrong prediction.
Raw API responses
solver
{
"reasoning": "ATPsynbetaL encodes a beta subunit-like component of the mitochondrial ATP synthase (Complex V), which catalyzes ATP synthesis via a rotational mechanism driven by the proton gradient across the inner mitochondrial membrane. The beta subunit contains the catalytic nucleotide-binding site where ADP is phosphorylated to ATP, making it central to oxidative phosphorylation efficiency. Proper Complex V function is essential for maintaining mitochondrial membrane potential, efficient energy production, and limiting reactive oxygen species (ROS) generation from upstream complexes. In Drosophila, reduced or dysfunctional ATP synthase activity leads to mitochondrial dysfunction, elevated ROS, and shortened lifespan. Conversely, normal or enhanced Complex V activity supports robust mitochondrial bioenergetics, which is consistently associated with healthy aging and longevity across model organisms.",
"confidence": 0.72,
"key_pathways": [
"oxidative phosphorylation / Complex V (ATP synthase)",
"mitochondrial proton gradient and membrane potential maintenance",
"mitochondrial ROS regulation"
],
"mechanism_class": "mitochondrial_dysfunction",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model predicted pro_longevity but the ground truth is anti_longevity. The model's reasoning assumes that normal/enhanced Complex V activity supports longevity, but the actual finding for ATPsynbetaL in Drosophila is anti-longevity (meaning the gene promotes aging/shortens lifespan, or its overexpression reduces lifespan). The model failed to consider that overexpression of ATP synthase components can be detrimental, or that this particular gene's activity negatively impacts longevity. The reasoning is plausible in general terms but leads to the wrong conclusion with moderate-high confidence (0.72), making this a confident wrong prediction.",
"failure_mode": "confident_wrong",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}