Eef1e1
M. musculus
eukaryotic translation elongation factor 1 epsilon 1
What the model saw
Gene: Eef1e1 Organism: Mus musculus Known functions: eukaryotic translation elongation factor 1 epsilon 1. eukaryotic translation elongation factor 1 epsilon-1. protein binding.
View unredacted entry
eukaryotic translation elongation factor 1 epsilon 1. eukaryotic translation elongation factor 1 epsilon-1. protein binding.
Solver output
Eef1e1 encodes a subunit of the eukaryotic translation elongation factor 1 (eEF1) complex, which is responsible for the GTP-dependent delivery of aminoacyl-tRNAs to the ribosomal A-site during mRNA translation. Accurate and efficient translation elongation is a core component of proteostasis; defects in this process lead to increased translational errors, misfolded proteins, and proteotoxic stress. The eEF1 complex also has a moonlighting role in aminoacyl-tRNA synthetase complex assembly (MARS complex), linking it to broader translational quality control. Maintenance of proteostasis through faithful translation is a well-established pro-longevity mechanism across model organisms. Loss of eEF1 subunit function is associated with reduced translational fidelity and accelerated aging phenotypes, supporting a pro-longevity role for its normal function.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted pro_longevity while the ground truth is anti_longevity. The model's reasoning about translation elongation and proteostasis is plausible in general terms, but it incorrectly applied this to Eef1e1 specifically. Eef1e1 (also known as p18/AIMP3) is actually a component of the multi-aminoacyl-tRNA synthetase complex (MARS complex) and has roles in DNA damage response and tumor suppression. Its anti-longevity designation likely reflects that it promotes aging-related processes (e.g., DNA damage signaling, p53 activation) rather than supporting longevity. The model's mechanistic reasoning conflated general translation elongation factors with this specific gene's actual biological role, leading to the wrong conclusion. Confidence was low (0.52) but still committed to the wrong answer.
Raw API responses
solver
{
"reasoning": "Eef1e1 encodes a subunit of the eukaryotic translation elongation factor 1 (eEF1) complex, which is responsible for the GTP-dependent delivery of aminoacyl-tRNAs to the ribosomal A-site during mRNA translation. Accurate and efficient translation elongation is a core component of proteostasis; defects in this process lead to increased translational errors, misfolded proteins, and proteotoxic stress. The eEF1 complex also has a moonlighting role in aminoacyl-tRNA synthetase complex assembly (MARS complex), linking it to broader translational quality control. Maintenance of proteostasis through faithful translation is a well-established pro-longevity mechanism across model organisms. Loss of eEF1 subunit function is associated with reduced translational fidelity and accelerated aging phenotypes, supporting a pro-longevity role for its normal function.",
"confidence": 0.52,
"key_pathways": [
"eukaryotic translation elongation (eEF1 complex)",
"proteostasis and translational quality control",
"aminoacyl-tRNA delivery to ribosome"
],
"mechanism_class": "loss_of_proteostasis",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model predicted pro_longevity while the ground truth is anti_longevity. The model's reasoning about translation elongation and proteostasis is plausible in general terms, but it incorrectly applied this to Eef1e1 specifically. Eef1e1 (also known as p18/AIMP3) is actually a component of the multi-aminoacyl-tRNA synthetase complex (MARS complex) and has roles in DNA damage response and tumor suppression. Its anti-longevity designation likely reflects that it promotes aging-related processes (e.g., DNA damage signaling, p53 activation) rather than supporting longevity. The model's mechanistic reasoning conflated general translation elongation factors with this specific gene's actual biological role, leading to the wrong conclusion. Confidence was low (0.52) but still committed to the wrong answer.",
"failure_mode": "confident_wrong",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}