laat-1
C. elegans
Lysosomal amino acid transporter 1
What the model saw
Gene: laat-1 Organism: Caenorhabditis elegans Known functions: Lysosomal amino acid transporter 1. L-arginine transmembrane transporter activity. L-lysine transmembrane transporter activity. basic amino acid transmembrane transporter activity.
View unredacted entry
Lysosomal amino acid transporter 1. L-arginine transmembrane transporter activity. L-lysine transmembrane transporter activity. basic amino acid transmembrane transporter activity.
Solver output
LAAT-1 is a lysosomal basic amino acid transporter that exports arginine and lysine from the lysosomal lumen into the cytoplasm. Lysosomal arginine export is a well-established activating signal for mTORC1 (via the SLC38A9/Ragulator/GATOR axis), and elevated cytoplasmic arginine levels promote mTORC1 activity. In C. elegans, mTORC1 (TORC1) activation suppresses autophagy and stress responses, thereby shortening lifespan. Loss of laat-1 function has been shown to reduce lysosomal arginine export, dampen TORC1 signaling, and extend lifespan, consistent with the gene's normal function being pro-aging (anti-longevity). This places laat-1 squarely within the deregulated nutrient-sensing hallmark, acting through the lysosomal amino acid sensing arm of the TORC1 pathway.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted anti_longevity for laat-1. The mechanistic reasoning is detailed and accurate: LAAT-1 exports basic amino acids (arginine/lysine) from the lysosome, activating TORC1 signaling, which suppresses autophagy and shortens lifespan. Loss of laat-1 reduces TORC1 activity and extends lifespan, making it anti-longevity. The model correctly identifies the lysosomal amino acid sensing arm of the TORC1 pathway as the key mechanism. Confidence of 0.72 is appropriate given the specificity of the gene.
Raw API responses
solver
{
"reasoning": "LAAT-1 is a lysosomal basic amino acid transporter that exports arginine and lysine from the lysosomal lumen into the cytoplasm. Lysosomal arginine export is a well-established activating signal for mTORC1 (via the SLC38A9/Ragulator/GATOR axis), and elevated cytoplasmic arginine levels promote mTORC1 activity. In C. elegans, mTORC1 (TORC1) activation suppresses autophagy and stress responses, thereby shortening lifespan. Loss of laat-1 function has been shown to reduce lysosomal arginine export, dampen TORC1 signaling, and extend lifespan, consistent with the gene's normal function being pro-aging (anti-longevity). This places laat-1 squarely within the deregulated nutrient-sensing hallmark, acting through the lysosomal amino acid sensing arm of the TORC1 pathway.",
"confidence": 0.72,
"key_pathways": [
"mTORC1/TORC1 nutrient sensing via lysosomal arginine export",
"lysosomal amino acid signaling (SLC38A9/Ragulator/GATOR axis)",
"autophagy suppression downstream of TORC1"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "anti_longevity"
}advisor
{
"notes": "The model correctly predicted anti_longevity for laat-1. The mechanistic reasoning is detailed and accurate: LAAT-1 exports basic amino acids (arginine/lysine) from the lysosome, activating TORC1 signaling, which suppresses autophagy and shortens lifespan. Loss of laat-1 reduces TORC1 activity and extends lifespan, making it anti-longevity. The model correctly identifies the lysosomal amino acid sensing arm of the TORC1 pathway as the key mechanism. Confidence of 0.72 is appropriate given the specificity of the gene.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 5,
"ground_truth_questionable": false
}