wwp-1
C. elegans
E3 ubiquitin-protein ligase wwp-1
What the model saw
Gene: wwp-1 Organism: Caenorhabditis elegans Known functions: E3 ubiquitin-protein ligase wwp-1. protein binding. ubiquitin conjugating enzyme activity. ubiquitin protein ligase activity. ubiquitin-protein transferase activity.
View unredacted entry
E3 ubiquitin-protein ligase wwp-1. protein binding. ubiquitin conjugating enzyme activity. ubiquitin protein ligase activity. ubiquitin-protein transferase activity.
Solver output
WWP-1 is a HECT-domain E3 ubiquitin ligase in C. elegans that has been shown to act downstream of dietary restriction to extend lifespan. Specifically, wwp-1 functions in the TOR/nutrient-sensing pathway and is required for the longevity benefits conferred by dietary restriction and reduced insulin/IGF-1 signaling. As an E3 ubiquitin ligase, WWP-1 ubiquitinates specific substrate proteins to modulate their stability or activity, and genetic studies in C. elegans have demonstrated that loss of wwp-1 suppresses lifespan extension under dietary restriction conditions. Its role in tagging substrates for proteasomal degradation within nutrient-sensing pathways places it as a pro-longevity factor that mediates the beneficial effects of caloric restriction on aging.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted wwp-1 as pro_longevity with reasonable confidence (0.72). The mechanistic reasoning is largely accurate - WWP-1 is indeed a HECT-domain E3 ubiquitin ligase that functions in dietary restriction-mediated longevity in C. elegans. The model correctly notes that loss of wwp-1 suppresses lifespan extension under dietary restriction. The mechanism class of "deregulated_nutrient_sensing" is appropriate given the dietary restriction/TOR pathway involvement. The reasoning is well-grounded in published literature. Minor note: the model slightly overstates the connection to insulin/IGF-1 signaling, as wwp-1's primary characterized role is more specifically in dietary restriction pathways, but this is a minor imprecision rather than an error.
Raw API responses
solver
{
"reasoning": "WWP-1 is a HECT-domain E3 ubiquitin ligase in C. elegans that has been shown to act downstream of dietary restriction to extend lifespan. Specifically, wwp-1 functions in the TOR/nutrient-sensing pathway and is required for the longevity benefits conferred by dietary restriction and reduced insulin/IGF-1 signaling. As an E3 ubiquitin ligase, WWP-1 ubiquitinates specific substrate proteins to modulate their stability or activity, and genetic studies in C. elegans have demonstrated that loss of wwp-1 suppresses lifespan extension under dietary restriction conditions. Its role in tagging substrates for proteasomal degradation within nutrient-sensing pathways places it as a pro-longevity factor that mediates the beneficial effects of caloric restriction on aging.",
"confidence": 0.72,
"key_pathways": [
"dietary restriction / TOR nutrient-sensing pathway",
"insulin/IGF-1 signaling (IIS) pathway",
"ubiquitin-proteasome system"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model correctly predicted wwp-1 as pro_longevity with reasonable confidence (0.72). The mechanistic reasoning is largely accurate - WWP-1 is indeed a HECT-domain E3 ubiquitin ligase that functions in dietary restriction-mediated longevity in C. elegans. The model correctly notes that loss of wwp-1 suppresses lifespan extension under dietary restriction. The mechanism class of \"deregulated_nutrient_sensing\" is appropriate given the dietary restriction/TOR pathway involvement. The reasoning is well-grounded in published literature. Minor note: the model slightly overstates the connection to insulin/IGF-1 signaling, as wwp-1's primary characterized role is more specifically in dietary restriction pathways, but this is a minor imprecision rather than an error.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 4,
"ground_truth_questionable": false
}