unc-83
C. elegans
KASH domain-containing protein;Nuclear migration protein unc-83
What the model saw
Gene: unc-83 Organism: Caenorhabditis elegans Known functions: KASH domain-containing protein;Nuclear migration protein unc-83. dynein light chain binding. protein binding.
View unredacted entry
KASH domain-containing protein;Nuclear migration protein unc-83. dynein light chain binding. protein binding.
Solver output
UNC-83 is a KASH domain-containing protein that resides in the outer nuclear membrane and forms part of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, mediating nuclear migration by connecting the nucleus to cytoplasmic dynein via dynein light chain binding. While nuclear positioning and nuclear envelope integrity are relevant to genomic stability and cellular organization, UNC-83's primary annotated role is in developmental nuclear migration (particularly in hypodermal and muscle cells) rather than in canonical aging pathways. There is no strong evidence that its normal function directly promotes or opposes longevity through established hallmarks of aging such as nutrient sensing, proteostasis, or mitochondrial function. The connection to nuclear envelope structure could theoretically link it to genomic instability, but this is speculative given the available annotations.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" with low confidence (0.35), but the ground truth is "anti_longevity." The model's reasoning focused on UNC-83's role in nuclear migration and the LINC complex, noting no strong connection to canonical aging pathways. While the mechanistic reasoning about UNC-83's developmental role is accurate, the model failed to identify that unc-83 has an anti-longevity influence in C. elegans. The model was appropriately uncertain but still got the answer wrong. The reasoning quality is limited because it didn't consider that loss-of-function of nuclear migration proteins can extend lifespan in C. elegans through mechanisms related to nuclear envelope stress responses or other pathways. The model's confidence of 0.35 reflects appropriate uncertainty, but the prediction of "unclear" rather than "anti_longevity" is incorrect.
Raw API responses
solver
{
"reasoning": "UNC-83 is a KASH domain-containing protein that resides in the outer nuclear membrane and forms part of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, mediating nuclear migration by connecting the nucleus to cytoplasmic dynein via dynein light chain binding. While nuclear positioning and nuclear envelope integrity are relevant to genomic stability and cellular organization, UNC-83's primary annotated role is in developmental nuclear migration (particularly in hypodermal and muscle cells) rather than in canonical aging pathways. There is no strong evidence that its normal function directly promotes or opposes longevity through established hallmarks of aging such as nutrient sensing, proteostasis, or mitochondrial function. The connection to nuclear envelope structure could theoretically link it to genomic instability, but this is speculative given the available annotations.",
"confidence": 0.35,
"key_pathways": [
"LINC complex / nuclear-cytoskeletal coupling",
"dynein-mediated nuclear migration",
"nuclear envelope integrity"
],
"mechanism_class": "other",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" with low confidence (0.35), but the ground truth is \"anti_longevity.\" The model's reasoning focused on UNC-83's role in nuclear migration and the LINC complex, noting no strong connection to canonical aging pathways. While the mechanistic reasoning about UNC-83's developmental role is accurate, the model failed to identify that unc-83 has an anti-longevity influence in C. elegans. The model was appropriately uncertain but still got the answer wrong. The reasoning quality is limited because it didn't consider that loss-of-function of nuclear migration proteins can extend lifespan in C. elegans through mechanisms related to nuclear envelope stress responses or other pathways. The model's confidence of 0.35 reflects appropriate uncertainty, but the prediction of \"unclear\" rather than \"anti_longevity\" is incorrect.",
"failure_mode": "confident_wrong",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}