old-1
C. elegans
Tyrosine-protein kinase receptor old-1
What the model saw
Gene: old-1 Organism: Caenorhabditis elegans Known functions: Tyrosine-protein kinase receptor old-1. ATP binding. protein kinase activity. protein tyrosine kinase activity. transmembrane receptor protein tyrosine kinase activity.
View unredacted entry
Tyrosine-protein kinase receptor old-1. ATP binding. protein kinase activity. protein tyrosine kinase activity. transmembrane receptor protein tyrosine kinase activity.
Solver output
old-1 (overexpressed in long-lived daf-2 mutants) encodes a transmembrane receptor tyrosine kinase in C. elegans. Its name derives from its upregulation in long-lived mutants, and it has been shown to be a positive regulator of lifespan when overexpressed. As a receptor tyrosine kinase, old-1 modulates downstream signaling cascades that intersect with the insulin/IGF-1 signaling (IIS) pathway — the central nutrient-sensing longevity axis in C. elegans. Overexpression of old-1 extends lifespan in a manner partially dependent on daf-16 (FOXO), suggesting it acts within or parallel to the IIS pathway to promote longevity. Unlike the canonical IIS receptor daf-2 (whose activity is anti-longevity), old-1 kinase activity appears to promote pro-longevity outputs, possibly by modulating DAF-16/FOXO nuclear localization or activity.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted pro_longevity for old-1. The reasoning is well-grounded: old-1 is indeed upregulated in long-lived daf-2 mutants, encodes a transmembrane receptor tyrosine kinase, and its overexpression extends lifespan in a daf-16-dependent manner. The mechanism class of "deregulated_nutrient_sensing" is reasonable given the connection to IIS/DAF-16 pathway, though old-1 is somewhat distinct from canonical nutrient sensing. The model correctly notes the contrast with daf-2 (anti-longevity) and old-1's pro-longevity role. Minor uncertainty about the exact mechanism class label, but overall the reasoning is accurate and well-supported.
Raw API responses
solver
{
"reasoning": "old-1 (overexpressed in long-lived daf-2 mutants) encodes a transmembrane receptor tyrosine kinase in C. elegans. Its name derives from its upregulation in long-lived mutants, and it has been shown to be a positive regulator of lifespan when overexpressed. As a receptor tyrosine kinase, old-1 modulates downstream signaling cascades that intersect with the insulin/IGF-1 signaling (IIS) pathway — the central nutrient-sensing longevity axis in C. elegans. Overexpression of old-1 extends lifespan in a manner partially dependent on daf-16 (FOXO), suggesting it acts within or parallel to the IIS pathway to promote longevity. Unlike the canonical IIS receptor daf-2 (whose activity is anti-longevity), old-1 kinase activity appears to promote pro-longevity outputs, possibly by modulating DAF-16/FOXO nuclear localization or activity.",
"confidence": 0.72,
"key_pathways": [
"insulin/IGF-1 signaling (IIS) pathway",
"DAF-16/FOXO transcription factor regulation",
"receptor tyrosine kinase signaling"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model correctly predicted pro_longevity for old-1. The reasoning is well-grounded: old-1 is indeed upregulated in long-lived daf-2 mutants, encodes a transmembrane receptor tyrosine kinase, and its overexpression extends lifespan in a daf-16-dependent manner. The mechanism class of \"deregulated_nutrient_sensing\" is reasonable given the connection to IIS/DAF-16 pathway, though old-1 is somewhat distinct from canonical nutrient sensing. The model correctly notes the contrast with daf-2 (anti-longevity) and old-1's pro-longevity role. Minor uncertainty about the exact mechanism class label, but overall the reasoning is accurate and well-supported.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 4,
"ground_truth_questionable": false
}