tba-7
C. elegans
Tubulin alpha chain
What the model saw
Gene: tba-7 Organism: Caenorhabditis elegans Known functions: Tubulin alpha chain. GTP binding. structural constituent of cytoskeleton.
View unredacted entry
Tubulin alpha chain. GTP binding. structural constituent of cytoskeleton.
Solver output
tba-7 encodes an alpha-tubulin subunit in C. elegans, functioning as a GTP-binding structural component of microtubules. Alpha-tubulin heterodimers with beta-tubulin to form microtubule polymers, which are essential for cell division, intracellular transport, and neuronal structure. While microtubule integrity is broadly important for cellular function, alpha-tubulin paralogs in C. elegans show tissue-specific and context-dependent roles, and no clear pro- or anti-longevity function has been established for tba-7 specifically. Microtubule dynamics intersect with multiple aging hallmarks (e.g., proteostasis via autophagy, stem cell function), but the net directionality for this particular paralog cannot be confidently assigned from molecular function annotations alone.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" while the ground truth is "anti_longevity." The model's reasoning is plausible given the limited information provided (only molecular function annotations), but it failed to assign the correct directionality. The model correctly identified tba-7 as an alpha-tubulin involved in microtubule dynamics but could not determine its anti-longevity role. This is a case where the model was appropriately uncertain given the sparse information, but still got the answer wrong. The confidence of 0.38 reflects genuine uncertainty, which is reasonable, but the prediction of "unclear" rather than attempting to assign a direction means it missed the correct answer.
Raw API responses
solver
{
"reasoning": "tba-7 encodes an alpha-tubulin subunit in C. elegans, functioning as a GTP-binding structural component of microtubules. Alpha-tubulin heterodimers with beta-tubulin to form microtubule polymers, which are essential for cell division, intracellular transport, and neuronal structure. While microtubule integrity is broadly important for cellular function, alpha-tubulin paralogs in C. elegans show tissue-specific and context-dependent roles, and no clear pro- or anti-longevity function has been established for tba-7 specifically. Microtubule dynamics intersect with multiple aging hallmarks (e.g., proteostasis via autophagy, stem cell function), but the net directionality for this particular paralog cannot be confidently assigned from molecular function annotations alone.",
"confidence": 0.38,
"key_pathways": [
"microtubule polymerization",
"intracellular cytoskeletal organization",
"GTP hydrolysis-driven tubulin dynamics"
],
"mechanism_class": "other",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" while the ground truth is \"anti_longevity.\" The model's reasoning is plausible given the limited information provided (only molecular function annotations), but it failed to assign the correct directionality. The model correctly identified tba-7 as an alpha-tubulin involved in microtubule dynamics but could not determine its anti-longevity role. This is a case where the model was appropriately uncertain given the sparse information, but still got the answer wrong. The confidence of 0.38 reflects genuine uncertainty, which is reasonable, but the prediction of \"unclear\" rather than attempting to assign a direction means it missed the correct answer.",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}