tes-1

C. elegans

uncharacterized protein

What the model saw

Gene: tes-1
Organism: Caenorhabditis elegans
Known functions: uncharacterized protein. zinc ion binding.

View unredacted entry

uncharacterized protein. zinc ion binding.

Solver output

Predicted influence

Unclear

Confidence

10%

Mechanism

Unclear

Reasoning

The gene tes-1 encodes an uncharacterized protein with only zinc ion binding activity annotated. Zinc ion binding is a broad molecular function shared by hundreds of structurally and functionally diverse proteins (e.g., transcription factors, metalloproteases, DNA repair enzymes, ubiquitin ligases), making it impossible to assign a specific aging-related pathway or mechanism without additional functional data. No known role in a defined longevity pathway in C. elegans can be inferred from these annotations alone. The lack of any characterized molecular process or biological function prevents a confident directional prediction.

Key pathways

zinc ion bindinguncharacterized molecular function

Longevity influence

Anti-longevity

Lifespan effect

Increase

GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.

Advisor judgment

Answer

✗Incorrect

Mechanism

✗Incorrect

Reasoning quality

2/5

Failure mode

Appropriately uncertain

Notes

The model predicted "unclear" with very low confidence (0.1), while the ground truth is "anti_longevity." The model's reasoning is understandable given the sparse annotations (uncharacterized protein with only zinc ion binding noted), but it failed to make a directional prediction. The model was appropriately uncertain given the limited information, but the answer is still wrong. No mechanism could be assessed since the model declined to propose one.

Raw API responses

solver

{
  "reasoning": "The gene tes-1 encodes an uncharacterized protein with only zinc ion binding activity annotated. Zinc ion binding is a broad molecular function shared by hundreds of structurally and functionally diverse proteins (e.g., transcription factors, metalloproteases, DNA repair enzymes, ubiquitin ligases), making it impossible to assign a specific aging-related pathway or mechanism without additional functional data. No known role in a defined longevity pathway in C. elegans can be inferred from these annotations alone. The lack of any characterized molecular process or biological function prevents a confident directional prediction.",
  "confidence": 0.1,
  "key_pathways": [
    "zinc ion binding",
    "uncharacterized molecular function"
  ],
  "mechanism_class": "unclear",
  "longevity_influence": "unclear"
}

advisor

{
  "notes": "The model predicted \"unclear\" with very low confidence (0.1), while the ground truth is \"anti_longevity.\" The model's reasoning is understandable given the sparse annotations (uncharacterized protein with only zinc ion binding noted), but it failed to make a directional prediction. The model was appropriately uncertain given the limited information, but the answer is still wrong. No mechanism could be assessed since the model declined to propose one.",
  "failure_mode": "appropriately_uncertain",
  "answer_correct": false,
  "mechanism_correct": false,
  "reasoning_quality": 2,
  "ground_truth_questionable": false
}