abcx-1
C. elegans
ABC transporter family G domain-containing protein
What the model saw
Gene: abcx-1 Organism: Caenorhabditis elegans Known functions: ABC transporter family G domain-containing protein. ABC-type transporter activity. ATPase-coupled transmembrane transporter activity.
View unredacted entry
ABC transporter family G domain-containing protein. ABC-type transporter activity. ATPase-coupled transmembrane transporter activity.
Solver output
abcx-1 encodes an ABC transporter family G (ABCG) domain-containing protein with ATPase-coupled transmembrane transport activity. ABCG transporters in C. elegans can mediate efflux of lipids, sterols, xenobiotics, or other substrates, but the specific substrate of abcx-1 is not defined by the available annotations. Without knowing the transported substrate, it is difficult to assign a clear pro- or anti-longevity role: if it exports toxic metabolites or supports lipid homeostasis it could be pro-longevity, but if it exports beneficial compounds or disrupts membrane lipid balance it could be anti-longevity. The molecular function annotations alone are too substrate-agnostic to confidently map this transporter to a specific aging hallmark or directional longevity effect.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" with low confidence (0.35), but the ground truth is "anti_longevity." The model's reasoning is plausible given the limited annotation information provided, but it failed to commit to the correct answer. The model correctly identified the gene as an ABC transporter and considered multiple possible roles, but could not determine the directionality. Since the ground truth is anti_longevity, the model's uncertainty was not rewarded here. The reasoning quality is modest - it correctly identifies the gene family and possible mechanisms but doesn't leverage any specific knowledge about abcx-1's role in C. elegans aging.
Raw API responses
solver
{
"reasoning": "abcx-1 encodes an ABC transporter family G (ABCG) domain-containing protein with ATPase-coupled transmembrane transport activity. ABCG transporters in C. elegans can mediate efflux of lipids, sterols, xenobiotics, or other substrates, but the specific substrate of abcx-1 is not defined by the available annotations. Without knowing the transported substrate, it is difficult to assign a clear pro- or anti-longevity role: if it exports toxic metabolites or supports lipid homeostasis it could be pro-longevity, but if it exports beneficial compounds or disrupts membrane lipid balance it could be anti-longevity. The molecular function annotations alone are too substrate-agnostic to confidently map this transporter to a specific aging hallmark or directional longevity effect.",
"confidence": 0.35,
"key_pathways": [
"ABC transporter-mediated efflux",
"lipid/sterol transport",
"xenobiotic detoxification"
],
"mechanism_class": "unclear",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" with low confidence (0.35), but the ground truth is \"anti_longevity.\" The model's reasoning is plausible given the limited annotation information provided, but it failed to commit to the correct answer. The model correctly identified the gene as an ABC transporter and considered multiple possible roles, but could not determine the directionality. Since the ground truth is anti_longevity, the model's uncertainty was not rewarded here. The reasoning quality is modest - it correctly identifies the gene family and possible mechanisms but doesn't leverage any specific knowledge about abcx-1's role in C. elegans aging.",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}