srw-99
C. elegans
G-protein coupled receptors family 1 profile domain-containing protein;G_PROTEIN_RECEP_F1_2 domain-containing protein
What the model saw
Gene: srw-99 Organism: Caenorhabditis elegans Known functions: G-protein coupled receptors family 1 profile domain-containing protein;G_PROTEIN_RECEP_F1_2 domain-containing protein. G protein-coupled peptide receptor activity.
View unredacted entry
G-protein coupled receptors family 1 profile domain-containing protein;G_PROTEIN_RECEP_F1_2 domain-containing protein. G protein-coupled peptide receptor activity.
Solver output
srw-99 encodes a serpentine (7-transmembrane) G protein-coupled receptor (GPCR) of the family 1 profile, with G protein-coupled peptide receptor activity. In C. elegans, GPCRs of this class are involved in chemosensory and neuroendocrine signaling, which can modulate lifespan through altered intercellular communication pathways. However, the srw (serpentine receptor, worm) family is extremely large (~1,300 members), and the specific ligand, downstream G-protein coupling (Gs, Gi, Gq), and effector pathway for srw-99 are not annotated. Without knowing whether this receptor activates pro-longevity pathways (e.g., DAF-16/FOXO via reduced insulin-like signaling) or anti-longevity pathways (e.g., promoting growth/reproduction signaling), the net effect on lifespan cannot be confidently determined from molecular function annotations alone.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" with low confidence (0.35), while the ground truth is "anti_longevity." The model's reasoning is sound given the limited information available - srw-99 is a member of the large serpentine receptor family with no specific ligand or pathway annotation provided. The model correctly identified the GPCR nature and relevant signaling pathways, but could not determine the directionality of the longevity effect. This is a case of appropriate uncertainty rather than a confident wrong answer, but the prediction is still incorrect relative to the ground truth. The mechanism class of "altered_intercellular_communication" is plausible but not confirmed as correct.
Raw API responses
solver
{
"reasoning": "srw-99 encodes a serpentine (7-transmembrane) G protein-coupled receptor (GPCR) of the family 1 profile, with G protein-coupled peptide receptor activity. In C. elegans, GPCRs of this class are involved in chemosensory and neuroendocrine signaling, which can modulate lifespan through altered intercellular communication pathways. However, the srw (serpentine receptor, worm) family is extremely large (~1,300 members), and the specific ligand, downstream G-protein coupling (Gs, Gi, Gq), and effector pathway for srw-99 are not annotated. Without knowing whether this receptor activates pro-longevity pathways (e.g., DAF-16/FOXO via reduced insulin-like signaling) or anti-longevity pathways (e.g., promoting growth/reproduction signaling), the net effect on lifespan cannot be confidently determined from molecular function annotations alone.",
"confidence": 0.35,
"key_pathways": [
"G protein-coupled receptor signaling",
"neuropeptide/peptide ligand signaling",
"neuroendocrine intercellular communication"
],
"mechanism_class": "altered_intercellular_communication",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" with low confidence (0.35), while the ground truth is \"anti_longevity.\" The model's reasoning is sound given the limited information available - srw-99 is a member of the large serpentine receptor family with no specific ligand or pathway annotation provided. The model correctly identified the GPCR nature and relevant signaling pathways, but could not determine the directionality of the longevity effect. This is a case of appropriate uncertainty rather than a confident wrong answer, but the prediction is still incorrect relative to the ground truth. The mechanism class of \"altered_intercellular_communication\" is plausible but not confirmed as correct.",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 3,
"ground_truth_questionable": false
}