acl-11
C. elegans
Phospholipid/glycerol acyltransferase domain-containing protein
What the model saw
Gene: acl-11 Organism: Caenorhabditis elegans Known functions: Phospholipid/glycerol acyltransferase domain-containing protein. acyltransferase activity.
View unredacted entry
Phospholipid/glycerol acyltransferase domain-containing protein. acyltransferase activity.
Solver output
acl-11 encodes a phospholipid/glycerol acyltransferase domain-containing protein with acyltransferase activity, placing it in lipid biosynthesis — specifically the acylation of glycerol backbones to form phospholipids or related lipid species. In C. elegans, lipid metabolism is tightly coupled to nutrient sensing pathways (e.g., DAF-2/IIS and AMPK), and membrane phospholipid composition can influence longevity. However, acyltransferases are a large and functionally diverse family; without knowing the specific lipid substrate, product, or downstream pathway affected by acl-11, it is not possible to confidently assign a pro- or anti-longevity role. The function annotation is too broad to distinguish whether this enzyme promotes beneficial membrane remodeling or contributes to lipotoxic lipid accumulation.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" while the ground truth is "anti_longevity." The model was appropriately uncertain given the limited information provided (only knowing it's a phospholipid/glycerol acyltransferase), but it still got the answer wrong. The model's reasoning about lipid metabolism and nutrient sensing is plausible but generic, and it failed to commit to a direction. The mechanism class of "deregulated_nutrient_sensing" is speculative and not well-supported by the evidence given. The model's low confidence (0.35) reflects its uncertainty, but it still chose the wrong answer category.
Raw API responses
solver
{
"reasoning": "acl-11 encodes a phospholipid/glycerol acyltransferase domain-containing protein with acyltransferase activity, placing it in lipid biosynthesis — specifically the acylation of glycerol backbones to form phospholipids or related lipid species. In C. elegans, lipid metabolism is tightly coupled to nutrient sensing pathways (e.g., DAF-2/IIS and AMPK), and membrane phospholipid composition can influence longevity. However, acyltransferases are a large and functionally diverse family; without knowing the specific lipid substrate, product, or downstream pathway affected by acl-11, it is not possible to confidently assign a pro- or anti-longevity role. The function annotation is too broad to distinguish whether this enzyme promotes beneficial membrane remodeling or contributes to lipotoxic lipid accumulation.",
"confidence": 0.35,
"key_pathways": [
"phospholipid biosynthesis",
"lipid metabolism / nutrient sensing",
"membrane remodeling"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" while the ground truth is \"anti_longevity.\" The model was appropriately uncertain given the limited information provided (only knowing it's a phospholipid/glycerol acyltransferase), but it still got the answer wrong. The model's reasoning about lipid metabolism and nutrient sensing is plausible but generic, and it failed to commit to a direction. The mechanism class of \"deregulated_nutrient_sensing\" is speculative and not well-supported by the evidence given. The model's low confidence (0.35) reflects its uncertainty, but it still chose the wrong answer category.",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}