ser-1
C. elegans
G-protein coupled receptors family 1 profile domain-containing protein
What the model saw
Gene: ser-1 Organism: Caenorhabditis elegans Known functions: G-protein coupled receptors family 1 profile domain-containing protein. G protein-coupled receptor activity. G protein-coupled serotonin receptor activity. amine binding. neurotransmitter receptor activity. serotonin binding.
View unredacted entry
G-protein coupled receptors family 1 profile domain-containing protein. G protein-coupled receptor activity. G protein-coupled serotonin receptor activity. amine binding. neurotransmitter receptor activity. serotonin binding.
Solver output
SER-1 is a G protein-coupled serotonin receptor (5-HT2-like) in C. elegans that mediates serotonergic intercellular signaling. Serotonin signaling in C. elegans is a key neuroendocrine communication pathway that modulates food sensing, metabolic state, and stress responses. Serotonin acts upstream of insulin/IGF-1-like signaling and TGF-β pathways, and serotonergic signaling through GPCRs can promote DAF-16/FOXO nuclear localization and stress resistance, which are pro-longevity outcomes. Additionally, serotonin signaling influences dietary restriction-like responses and fat metabolism in C. elegans, both of which are linked to lifespan extension. The receptor's role in integrating environmental nutrient cues with neuroendocrine outputs places it within the altered intercellular communication hallmark of aging, where intact serotonergic signaling supports organismal homeostasis and longevity.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted pro_longevity but the ground truth is anti_longevity. The model's reasoning about serotonin signaling promoting longevity through DAF-16/FOXO and stress resistance is speculative and ultimately incorrect for this specific receptor. SER-1 is actually anti-longevity in C. elegans, meaning its loss or reduction extends lifespan. The model constructed a plausible-sounding but incorrect mechanistic narrative, and while confidence was only 0.55, the prediction was still wrong in both direction and mechanism.
Raw API responses
solver
{
"reasoning": "SER-1 is a G protein-coupled serotonin receptor (5-HT2-like) in C. elegans that mediates serotonergic intercellular signaling. Serotonin signaling in C. elegans is a key neuroendocrine communication pathway that modulates food sensing, metabolic state, and stress responses. Serotonin acts upstream of insulin/IGF-1-like signaling and TGF-β pathways, and serotonergic signaling through GPCRs can promote DAF-16/FOXO nuclear localization and stress resistance, which are pro-longevity outcomes. Additionally, serotonin signaling influences dietary restriction-like responses and fat metabolism in C. elegans, both of which are linked to lifespan extension. The receptor's role in integrating environmental nutrient cues with neuroendocrine outputs places it within the altered intercellular communication hallmark of aging, where intact serotonergic signaling supports organismal homeostasis and longevity.",
"confidence": 0.55,
"key_pathways": [
"serotonin/5-HT GPCR signaling",
"neuroendocrine intercellular communication",
"insulin/IGF-1 signaling modulation via serotonin"
],
"mechanism_class": "altered_intercellular_communication",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model predicted pro_longevity but the ground truth is anti_longevity. The model's reasoning about serotonin signaling promoting longevity through DAF-16/FOXO and stress resistance is speculative and ultimately incorrect for this specific receptor. SER-1 is actually anti-longevity in C. elegans, meaning its loss or reduction extends lifespan. The model constructed a plausible-sounding but incorrect mechanistic narrative, and while confidence was only 0.55, the prediction was still wrong in both direction and mechanism.",
"failure_mode": "confident_wrong",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}