RPS6B
S. cerevisiae
40S ribosomal protein eS6 RPS6B
What the model saw
Gene: RPS6B Organism: Saccharomyces cerevisiae Known functions: 40S ribosomal protein eS6 RPS6B. structural constituent of ribosome.
View unredacted entry
40S ribosomal protein eS6 RPS6B. structural constituent of ribosome.
Solver output
RPS6B encodes the 40S ribosomal protein eS6, a structural component of the small ribosomal subunit. In yeast, ribosomal protein S6 is a well-characterized downstream target of the TORC1-S6 kinase (Sch9) signaling axis, which is a central nutrient-sensing pathway. Hyperactivation of TORC1 signaling and increased ribosome biogenesis are associated with accelerated aging, while downregulation of this pathway (e.g., via rapamycin or deletion of ribosomal protein genes) extends lifespan. Deletion of ribosomal protein genes, including RPS6B, has been shown to extend chronological and replicative lifespan in S. cerevisiae, consistent with reduced translational capacity relieving pro-aging TORC1-driven anabolism. Thus, the normal function of RPS6B — promoting ribosome assembly and protein synthesis downstream of nutrient sensing — opposes longevity.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted anti_longevity for RPS6B. The mechanistic reasoning is excellent: it correctly identifies RPS6B as a downstream target of the TORC1-S6K (Sch9) signaling axis, explains that deletion of ribosomal protein genes including RPS6B extends lifespan in yeast, and correctly frames the normal function of RPS6B as pro-aging (anti-longevity) by promoting ribosome assembly and protein synthesis. The confidence of 0.75 is appropriate. All key pathways identified are relevant and accurate.
Raw API responses
solver
{
"reasoning": "RPS6B encodes the 40S ribosomal protein eS6, a structural component of the small ribosomal subunit. In yeast, ribosomal protein S6 is a well-characterized downstream target of the TORC1-S6 kinase (Sch9) signaling axis, which is a central nutrient-sensing pathway. Hyperactivation of TORC1 signaling and increased ribosome biogenesis are associated with accelerated aging, while downregulation of this pathway (e.g., via rapamycin or deletion of ribosomal protein genes) extends lifespan. Deletion of ribosomal protein genes, including RPS6B, has been shown to extend chronological and replicative lifespan in S. cerevisiae, consistent with reduced translational capacity relieving pro-aging TORC1-driven anabolism. Thus, the normal function of RPS6B — promoting ribosome assembly and protein synthesis downstream of nutrient sensing — opposes longevity.",
"confidence": 0.75,
"key_pathways": [
"TORC1-S6K nutrient sensing",
"ribosome biogenesis",
"translational regulation"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "anti_longevity"
}advisor
{
"notes": "The model correctly predicted anti_longevity for RPS6B. The mechanistic reasoning is excellent: it correctly identifies RPS6B as a downstream target of the TORC1-S6K (Sch9) signaling axis, explains that deletion of ribosomal protein genes including RPS6B extends lifespan in yeast, and correctly frames the normal function of RPS6B as pro-aging (anti-longevity) by promoting ribosome assembly and protein synthesis. The confidence of 0.75 is appropriate. All key pathways identified are relevant and accurate.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 5,
"ground_truth_questionable": false
}