RPL6B
S. cerevisiae
60S ribosomal protein eL6 RPL6B
What the model saw
Gene: RPL6B Organism: Saccharomyces cerevisiae Known functions: 60S ribosomal protein eL6 RPL6B. RNA binding. structural constituent of ribosome.
View unredacted entry
60S ribosomal protein eL6 RPL6B. RNA binding. structural constituent of ribosome.
Solver output
RPL6B encodes a structural component of the 60S ribosomal large subunit (eL6), directly contributing to ribosome biogenesis and translational capacity. In yeast, reduced ribosomal protein gene dosage — particularly of 60S subunit components — is well-established to extend chronological and replicative lifespan, largely through attenuation of TORC1-driven protein synthesis. Deletion of large-subunit ribosomal protein genes mimics the pro-longevity effects of rapamycin or dietary restriction by decreasing global translation rates and reducing proteotoxic burden. The normal function of RPL6B thus promotes high translational output, which is associated with accelerated aging in yeast. This places RPL6B's activity squarely within the deregulated nutrient-sensing hallmark, as ribosome abundance is a key downstream effector of TOR signaling.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted anti_longevity for RPL6B with high confidence (0.72). The mechanistic reasoning is sound and well-articulated: RPL6B encodes a 60S ribosomal large subunit protein, and deletion of ribosomal protein genes in yeast is well-known to extend lifespan by reducing translational output and mimicking dietary restriction/TOR inhibition. The model correctly identifies that the normal (wild-type) function of RPL6B promotes high translation rates, which accelerates aging — making it anti-longevity. The mechanism class of "deregulated_nutrient_sensing" is reasonable given the TOR-ribosome biogenesis connection, though one could also classify it under proteostasis or translational regulation. Overall, the prediction and reasoning are both correct and well-supported.
Raw API responses
solver
{
"reasoning": "RPL6B encodes a structural component of the 60S ribosomal large subunit (eL6), directly contributing to ribosome biogenesis and translational capacity. In yeast, reduced ribosomal protein gene dosage — particularly of 60S subunit components — is well-established to extend chronological and replicative lifespan, largely through attenuation of TORC1-driven protein synthesis. Deletion of large-subunit ribosomal protein genes mimics the pro-longevity effects of rapamycin or dietary restriction by decreasing global translation rates and reducing proteotoxic burden. The normal function of RPL6B thus promotes high translational output, which is associated with accelerated aging in yeast. This places RPL6B's activity squarely within the deregulated nutrient-sensing hallmark, as ribosome abundance is a key downstream effector of TOR signaling.",
"confidence": 0.72,
"key_pathways": [
"TORC1-ribosome biogenesis axis",
"60S ribosomal large subunit assembly",
"translational regulation and proteostasis"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "anti_longevity"
}advisor
{
"notes": "The model correctly predicted anti_longevity for RPL6B with high confidence (0.72). The mechanistic reasoning is sound and well-articulated: RPL6B encodes a 60S ribosomal large subunit protein, and deletion of ribosomal protein genes in yeast is well-known to extend lifespan by reducing translational output and mimicking dietary restriction/TOR inhibition. The model correctly identifies that the normal (wild-type) function of RPL6B promotes high translation rates, which accelerates aging — making it anti-longevity. The mechanism class of \"deregulated_nutrient_sensing\" is reasonable given the TOR-ribosome biogenesis connection, though one could also classify it under proteostasis or translational regulation. Overall, the prediction and reasoning are both correct and well-supported.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 5,
"ground_truth_questionable": false
}