RPL31A
S. cerevisiae
60S ribosomal protein eL31 RPL31A
What the model saw
Gene: RPL31A Organism: Saccharomyces cerevisiae Known functions: 60S ribosomal protein eL31 RPL31A. structural constituent of ribosome.
View unredacted entry
60S ribosomal protein eL31 RPL31A. structural constituent of ribosome.
Solver output
RPL31A encodes the 60S ribosomal large subunit protein eL31, a structural constituent of the ribosome. Ribosome biogenesis and translational capacity are tightly coupled to TOR (Target of Rapamycin) nutrient-sensing signaling in yeast. Elevated ribosomal activity downstream of TORC1 promotes growth but accelerates aging, and deletion of individual ribosomal protein genes — particularly those of the large subunit — is one of the most reproducible interventions that extends chronological and replicative lifespan in S. cerevisiae. Reduced ribosomal protein dosage (e.g., rpl31aΔ) decreases global translation rates, mimicking the pro-longevity effects of TOR inhibition or dietary restriction. Thus, the normal function of RPL31A (supporting full ribosomal capacity) opposes longevity by sustaining high anabolic flux associated with accelerated aging.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted anti_longevity for RPL31A. The mechanistic reasoning is sound and well-articulated: RPL31A encodes a 60S ribosomal large subunit protein, and deletion of ribosomal protein genes (especially large subunit) is well-established to extend lifespan in yeast by reducing translational capacity and mimicking TOR inhibition/dietary restriction. The mechanism class of "deregulated_nutrient_sensing" is appropriate given the TOR-ribosome biogenesis connection. The confidence of 0.72 is reasonable. Overall, this is an excellent prediction with correct answer and correct mechanistic reasoning.
Raw API responses
solver
{
"reasoning": "RPL31A encodes the 60S ribosomal large subunit protein eL31, a structural constituent of the ribosome. Ribosome biogenesis and translational capacity are tightly coupled to TOR (Target of Rapamycin) nutrient-sensing signaling in yeast. Elevated ribosomal activity downstream of TORC1 promotes growth but accelerates aging, and deletion of individual ribosomal protein genes — particularly those of the large subunit — is one of the most reproducible interventions that extends chronological and replicative lifespan in S. cerevisiae. Reduced ribosomal protein dosage (e.g., rpl31aΔ) decreases global translation rates, mimicking the pro-longevity effects of TOR inhibition or dietary restriction. Thus, the normal function of RPL31A (supporting full ribosomal capacity) opposes longevity by sustaining high anabolic flux associated with accelerated aging.",
"confidence": 0.72,
"key_pathways": [
"TORC1-ribosome biogenesis axis",
"translational regulation and dietary restriction mimicry",
"60S ribosomal large subunit assembly"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "anti_longevity"
}advisor
{
"notes": "The model correctly predicted anti_longevity for RPL31A. The mechanistic reasoning is sound and well-articulated: RPL31A encodes a 60S ribosomal large subunit protein, and deletion of ribosomal protein genes (especially large subunit) is well-established to extend lifespan in yeast by reducing translational capacity and mimicking TOR inhibition/dietary restriction. The mechanism class of \"deregulated_nutrient_sensing\" is appropriate given the TOR-ribosome biogenesis connection. The confidence of 0.72 is reasonable. Overall, this is an excellent prediction with correct answer and correct mechanistic reasoning.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 5,
"ground_truth_questionable": false
}