r08e3.3
C. elegans
CCDC22 N-terminal domain-containing protein
What the model saw
Gene: R08E3.3 Organism: Caenorhabditis elegans Known functions: CCDC22 N-terminal domain-containing protein. cullin family protein binding.
View unredacted entry
CCDC22 N-terminal domain-containing protein. cullin family protein binding.
Solver output
R08E3.3 encodes a CCDC22 N-terminal domain-containing protein with cullin family protein binding activity. In mammals, CCDC22 is a component of the CCC (CCDC22-CCDC93-COMMD) complex involved in endosomal cargo recycling and NF-κB regulation. Cullin binding suggests involvement in cullin-RING ubiquitin ligase (CRL) complexes, which regulate protein degradation via the ubiquitin-proteasome system. However, the specific substrate targets and whether this protein acts as an activator or inhibitor of CRL activity in C. elegans are not determinable from these annotations alone. The dual potential roles — modulating proteostasis via ubiquitin ligase regulation or influencing NF-κB/inflammatory signaling — present conflicting longevity implications without further functional data.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" with low confidence (0.35), but the ground truth is "anti_longevity." The model's reasoning about CCDC22/CCC complex and cullin-RING ubiquitin ligase involvement is plausible but doesn't lead to the correct conclusion. The model hedged excessively rather than making a directional prediction. The mechanistic reasoning is speculative and doesn't correctly identify the anti-longevity role. Given the gene's cullin binding function, one might reason that it promotes protein degradation of longevity-promoting factors, but the model failed to commit to any direction.
Raw API responses
solver
{
"reasoning": "R08E3.3 encodes a CCDC22 N-terminal domain-containing protein with cullin family protein binding activity. In mammals, CCDC22 is a component of the CCC (CCDC22-CCDC93-COMMD) complex involved in endosomal cargo recycling and NF-κB regulation. Cullin binding suggests involvement in cullin-RING ubiquitin ligase (CRL) complexes, which regulate protein degradation via the ubiquitin-proteasome system. However, the specific substrate targets and whether this protein acts as an activator or inhibitor of CRL activity in C. elegans are not determinable from these annotations alone. The dual potential roles — modulating proteostasis via ubiquitin ligase regulation or influencing NF-κB/inflammatory signaling — present conflicting longevity implications without further functional data.",
"confidence": 0.35,
"key_pathways": [
"cullin-RING ubiquitin ligase (CRL) complex regulation",
"endosomal cargo recycling (CCC complex)",
"ubiquitin-proteasome system"
],
"mechanism_class": "other",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" with low confidence (0.35), but the ground truth is \"anti_longevity.\" The model's reasoning about CCDC22/CCC complex and cullin-RING ubiquitin ligase involvement is plausible but doesn't lead to the correct conclusion. The model hedged excessively rather than making a directional prediction. The mechanistic reasoning is speculative and doesn't correctly identify the anti-longevity role. Given the gene's cullin binding function, one might reason that it promotes protein degradation of longevity-promoting factors, but the model failed to commit to any direction.",
"failure_mode": "confident_wrong",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}