PHB1
S. cerevisiae
prohibitin subunit PHB1
What the model saw
Gene: PHB1 Organism: Saccharomyces cerevisiae Known functions: prohibitin subunit PHB1. mitochondrion autophagosome adaptor activity. protein binding.
View unredacted entry
prohibitin subunit PHB1. mitochondrion autophagosome adaptor activity. protein binding.
Solver output
PHB1 encodes a subunit of the prohibitin complex (PHB1/PHB2), which localizes to the inner mitochondrial membrane and plays a critical role in maintaining mitochondrial membrane integrity, cristae morphology, and mitochondrial protein quality control. The prohibitin complex acts as a scaffold that stabilizes respiratory chain complexes and protects against mitochondrial dysfunction, thereby supporting mitochondrial health during aging. Additionally, PHB1's annotated "mitochondrion autophagosome adaptor activity" suggests a role in mitophagy — the selective autophagic clearance of damaged mitochondria — which is a key pro-longevity mechanism that prevents accumulation of dysfunctional mitochondria. In yeast, loss of PHB1 leads to shortened replicative lifespan and accelerated aging phenotypes, consistent with a pro-longevity function. By preserving mitochondrial quality through both structural support and mitophagy-mediated turnover, PHB1 opposes a central hallmark of aging.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted PHB1 as pro_longevity with high confidence (0.78). The mechanistic reasoning is thorough and accurate: PHB1 is indeed a subunit of the prohibitin complex that localizes to the inner mitochondrial membrane, maintains mitochondrial integrity, stabilizes respiratory chain complexes, and participates in mitophagy. The model correctly notes that loss of PHB1 leads to shortened replicative lifespan in yeast. The reasoning integrates both structural (prohibitin complex scaffold) and functional (mitophagy adaptor) roles of PHB1 in a coherent pro-longevity narrative. All key pathways identified are relevant and accurate.
Raw API responses
solver
{
"reasoning": "PHB1 encodes a subunit of the prohibitin complex (PHB1/PHB2), which localizes to the inner mitochondrial membrane and plays a critical role in maintaining mitochondrial membrane integrity, cristae morphology, and mitochondrial protein quality control. The prohibitin complex acts as a scaffold that stabilizes respiratory chain complexes and protects against mitochondrial dysfunction, thereby supporting mitochondrial health during aging. Additionally, PHB1's annotated \"mitochondrion autophagosome adaptor activity\" suggests a role in mitophagy — the selective autophagic clearance of damaged mitochondria — which is a key pro-longevity mechanism that prevents accumulation of dysfunctional mitochondria. In yeast, loss of PHB1 leads to shortened replicative lifespan and accelerated aging phenotypes, consistent with a pro-longevity function. By preserving mitochondrial quality through both structural support and mitophagy-mediated turnover, PHB1 opposes a central hallmark of aging.",
"confidence": 0.78,
"key_pathways": [
"mitochondrial protein quality control",
"mitophagy / selective autophagy",
"respiratory chain complex stabilization"
],
"mechanism_class": "mitochondrial_dysfunction",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model correctly predicted PHB1 as pro_longevity with high confidence (0.78). The mechanistic reasoning is thorough and accurate: PHB1 is indeed a subunit of the prohibitin complex that localizes to the inner mitochondrial membrane, maintains mitochondrial integrity, stabilizes respiratory chain complexes, and participates in mitophagy. The model correctly notes that loss of PHB1 leads to shortened replicative lifespan in yeast. The reasoning integrates both structural (prohibitin complex scaffold) and functional (mitophagy adaptor) roles of PHB1 in a coherent pro-longevity narrative. All key pathways identified are relevant and accurate.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 5,
"ground_truth_questionable": false
}