Mnt
D. melanogaster
Mnt
What the model saw
Gene: Mnt Organism: Drosophila melanogaster Known functions: Mnt. DNA binding. DNA-binding transcription factor activity. DNA-binding transcription factor activity, RNA polymerase II-specific. RNA polymerase II cis-regulatory region sequence-specific DNA binding. protein binding. protein dimerization activity. protein heterodimerization activity. sequence-specific DNA binding.
View unredacted entry
Mnt. DNA binding. DNA-binding transcription factor activity. DNA-binding transcription factor activity, RNA polymerase II-specific. RNA polymerase II cis-regulatory region sequence-specific DNA binding. protein binding. protein dimerization activity. protein heterodimerization activity. sequence-specific DNA binding.
Solver output
Mnt (Max Network Transcriptional Repressor) is a member of the Myc/Max/Mad transcriptional network. It heterodimerizes with Max via its bHLH-LZ domain and binds E-box sequences to repress Myc target genes, acting as a functional antagonist of Myc. Since Myc is a potent driver of cellular growth, proliferation, and anabolic metabolism (including ribosome biogenesis and nutrient sensing pathways), Mnt-mediated repression of Myc targets would dampen these pro-growth signals. Reduced Myc activity is broadly associated with lifespan extension in multiple model organisms, including Drosophila, where decreased Myc/TOR-driven anabolism promotes longevity. Thus, Mnt's role as a transcriptional repressor that counteracts Myc places it in the deregulated nutrient sensing hallmark, as Myc is a key downstream effector of nutrient/growth signaling. By restraining Myc-driven transcription, Mnt is predicted to be pro-longevity.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted pro_longevity for Mnt in Drosophila. The mechanistic reasoning is sound and well-articulated: Mnt as a Max-binding transcriptional repressor that antagonizes Myc, with reduced Myc activity being associated with lifespan extension. The classification as "deregulated_nutrient_sensing" is reasonable given the Myc/TOR connection, though Mnt's role is primarily as a transcriptional repressor in the Myc network rather than a direct nutrient sensor. The reasoning is biologically coherent and the confidence level (0.68) is appropriately calibrated. Minor quibble: the mechanism could also be framed as transcriptional regulation rather than nutrient sensing per se, but the connection drawn is valid.
Raw API responses
solver
{
"reasoning": "Mnt (Max Network Transcriptional Repressor) is a member of the Myc/Max/Mad transcriptional network. It heterodimerizes with Max via its bHLH-LZ domain and binds E-box sequences to repress Myc target genes, acting as a functional antagonist of Myc. Since Myc is a potent driver of cellular growth, proliferation, and anabolic metabolism (including ribosome biogenesis and nutrient sensing pathways), Mnt-mediated repression of Myc targets would dampen these pro-growth signals. Reduced Myc activity is broadly associated with lifespan extension in multiple model organisms, including Drosophila, where decreased Myc/TOR-driven anabolism promotes longevity. Thus, Mnt's role as a transcriptional repressor that counteracts Myc places it in the deregulated nutrient sensing hallmark, as Myc is a key downstream effector of nutrient/growth signaling. By restraining Myc-driven transcription, Mnt is predicted to be pro-longevity.",
"confidence": 0.68,
"key_pathways": [
"Myc/Max/Mad transcriptional network",
"E-box-mediated transcriptional repression",
"TOR/Myc nutrient sensing axis"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model correctly predicted pro_longevity for Mnt in Drosophila. The mechanistic reasoning is sound and well-articulated: Mnt as a Max-binding transcriptional repressor that antagonizes Myc, with reduced Myc activity being associated with lifespan extension. The classification as \"deregulated_nutrient_sensing\" is reasonable given the Myc/TOR connection, though Mnt's role is primarily as a transcriptional repressor in the Myc network rather than a direct nutrient sensor. The reasoning is biologically coherent and the confidence level (0.68) is appropriately calibrated. Minor quibble: the mechanism could also be framed as transcriptional regulation rather than nutrient sensing per se, but the connection drawn is valid.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 4,
"ground_truth_questionable": false
}