lbp-9
C. elegans
Cytosolic fatty-acid binding proteins domain-containing protein;Fatty acid-binding protein homolog 9
What the model saw
Gene: lbp-9 Organism: Caenorhabditis elegans Known functions: Cytosolic fatty-acid binding proteins domain-containing protein;Fatty acid-binding protein homolog 9. fatty acid binding. lipid binding.
View unredacted entry
Cytosolic fatty-acid binding proteins domain-containing protein;Fatty acid-binding protein homolog 9. fatty acid binding. lipid binding.
Solver output
lbp-9 encodes a cytosolic fatty acid-binding protein (FABP) in C. elegans, which functions to bind and chaperone fatty acids and other lipid ligands intracellularly. FABPs in C. elegans, including lbp-9, have been linked to nuclear hormone receptor signaling — particularly the NHR-49/PPARα-like pathway — by delivering fatty acid ligands to transcription factors that regulate lipid metabolism and stress responses. Activation of lipid oxidation and fatty acid catabolism pathways downstream of NHR-49 is associated with extended lifespan in C. elegans. Additionally, FABPs can modulate lipid droplet dynamics and membrane composition, influencing mitochondrial function and oxidative stress resilience. Proper intracellular lipid trafficking via lbp-9 supports metabolic homeostasis, which is a key determinant of longevity in this organism.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted lbp-9 as pro_longevity with reasonable confidence (0.62). The mechanistic reasoning is plausible and well-grounded — lbp-9 is indeed a fatty acid-binding protein in C. elegans, and the connection to NHR-49/PPARα-like signaling and lipid metabolic homeostasis is a reasonable mechanistic explanation for its pro-longevity role. The reasoning is coherent and consistent with known C. elegans biology around lipid signaling and longevity. The mechanism class of "deregulated_nutrient_sensing" is a reasonable categorization, though lipid signaling/transport might be more precise. Overall a solid prediction with good mechanistic reasoning.
Raw API responses
solver
{
"reasoning": "lbp-9 encodes a cytosolic fatty acid-binding protein (FABP) in C. elegans, which functions to bind and chaperone fatty acids and other lipid ligands intracellularly. FABPs in C. elegans, including lbp-9, have been linked to nuclear hormone receptor signaling — particularly the NHR-49/PPARα-like pathway — by delivering fatty acid ligands to transcription factors that regulate lipid metabolism and stress responses. Activation of lipid oxidation and fatty acid catabolism pathways downstream of NHR-49 is associated with extended lifespan in C. elegans. Additionally, FABPs can modulate lipid droplet dynamics and membrane composition, influencing mitochondrial function and oxidative stress resilience. Proper intracellular lipid trafficking via lbp-9 supports metabolic homeostasis, which is a key determinant of longevity in this organism.",
"confidence": 0.62,
"key_pathways": [
"NHR-49/PPARα fatty acid signaling",
"intracellular lipid trafficking and fatty acid catabolism",
"lipid metabolic homeostasis"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model correctly predicted lbp-9 as pro_longevity with reasonable confidence (0.62). The mechanistic reasoning is plausible and well-grounded — lbp-9 is indeed a fatty acid-binding protein in C. elegans, and the connection to NHR-49/PPARα-like signaling and lipid metabolic homeostasis is a reasonable mechanistic explanation for its pro-longevity role. The reasoning is coherent and consistent with known C. elegans biology around lipid signaling and longevity. The mechanism class of \"deregulated_nutrient_sensing\" is a reasonable categorization, though lipid signaling/transport might be more precise. Overall a solid prediction with good mechanistic reasoning.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 4,
"ground_truth_questionable": false
}