inx-14
C. elegans
Innexin-14
What the model saw
Gene: inx-14 Organism: Caenorhabditis elegans Known functions: Innexin-14. gap junction channel activity. gap junction hemi-channel activity.
View unredacted entry
Innexin-14. gap junction channel activity. gap junction hemi-channel activity.
Solver output
INX-14 is a C. elegans innexin that forms gap junction channels and hemichannels, enabling direct intercellular communication between cells. In C. elegans, gap junctions mediated by innexins (particularly INX-14) are known to coordinate systemic signaling, including the propagation of germline signals that influence somatic aging and the transmission of stress-response signals across tissues. Loss of gap junction communication can disrupt coordinated tissue homeostasis and inter-tissue signaling that supports longevity, such as the relay of insulin/IGF-1-like signaling cues or mitochondrial stress signals between the germline and soma. INX-14 specifically has been implicated in germline-to-soma communication that modulates lifespan, suggesting its normal function facilitates pro-longevity intercellular coordination. Disruption of this channel activity impairs the systemic integration of metabolic and stress signals, which is detrimental to organismal longevity.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted pro_longevity but the ground truth is anti_longevity. The model reasoned that INX-14 facilitates pro-longevity intercellular communication, so its loss would be detrimental. However, the ground truth indicates inx-14 is anti_longevity, meaning its normal function actually shortens lifespan (or its loss extends lifespan). The mechanistic reasoning is also incorrect - INX-14 gap junction activity appears to be detrimental to longevity rather than beneficial. The model's reasoning about germline-to-soma communication being pro-longevity via INX-14 is not supported by the actual data. The model had moderate confidence (0.55) but was still wrong in both the answer and the mechanism.
Raw API responses
solver
{
"reasoning": "INX-14 is a C. elegans innexin that forms gap junction channels and hemichannels, enabling direct intercellular communication between cells. In C. elegans, gap junctions mediated by innexins (particularly INX-14) are known to coordinate systemic signaling, including the propagation of germline signals that influence somatic aging and the transmission of stress-response signals across tissues. Loss of gap junction communication can disrupt coordinated tissue homeostasis and inter-tissue signaling that supports longevity, such as the relay of insulin/IGF-1-like signaling cues or mitochondrial stress signals between the germline and soma. INX-14 specifically has been implicated in germline-to-soma communication that modulates lifespan, suggesting its normal function facilitates pro-longevity intercellular coordination. Disruption of this channel activity impairs the systemic integration of metabolic and stress signals, which is detrimental to organismal longevity.",
"confidence": 0.55,
"key_pathways": [
"gap junction-mediated intercellular communication",
"germline-to-soma signaling",
"systemic stress response coordination"
],
"mechanism_class": "altered_intercellular_communication",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model predicted pro_longevity but the ground truth is anti_longevity. The model reasoned that INX-14 facilitates pro-longevity intercellular communication, so its loss would be detrimental. However, the ground truth indicates inx-14 is anti_longevity, meaning its normal function actually shortens lifespan (or its loss extends lifespan). The mechanistic reasoning is also incorrect - INX-14 gap junction activity appears to be detrimental to longevity rather than beneficial. The model's reasoning about germline-to-soma communication being pro-longevity via INX-14 is not supported by the actual data. The model had moderate confidence (0.55) but was still wrong in both the answer and the mechanism.",
"failure_mode": "confident_wrong",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}