hrpa-1
C. elegans
Heterogeneous nuclear ribonucleoprotein A1
What the model saw
Gene: hrpa-1 Organism: Caenorhabditis elegans Known functions: Heterogeneous nuclear ribonucleoprotein A1. RNA binding. mRNA 3'-UTR binding. nucleic acid binding.
View unredacted entry
Heterogeneous nuclear ribonucleoprotein A1. RNA binding. mRNA 3'-UTR binding. nucleic acid binding.
Solver output
HRPA-1 is the C. elegans ortholog of mammalian hnRNP A1, an RNA-binding protein that regulates post-transcriptional gene expression by binding mRNA 3'-UTRs and modulating mRNA stability, splicing, and translation. In the context of aging, hnRNP-family proteins are known to regulate the expression of stress-response and longevity-associated transcripts, including those in the DAF-16/FOXO and heat-shock response pathways, through 3'-UTR interactions. Post-transcriptional regulation of mRNA stability is a key component of proteostasis and stress-response networks that support longevity in C. elegans. Loss of such RNA-binding regulators can impair the proper expression of protective genes, suggesting a pro-longevity role. However, the specific targets of hrpa-1 in C. elegans are not fully characterized, introducing some uncertainty.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted pro_longevity while the ground truth is anti_longevity. The model's reasoning is generic and speculative, invoking DAF-16/FOXO pathways without specific evidence for hrpa-1. The model correctly identifies hrpa-1 as an RNA-binding protein involved in post-transcriptional regulation, but incorrectly infers a pro-longevity role. In reality, hrpa-1 is anti-longevity, meaning its loss likely extends lifespan. The model's logic (loss of RNA-binding regulators impairs protective gene expression → pro-longevity) is the opposite of what the data shows. The confidence of 0.52 is low but still leans wrong. The mechanism class of "epigenetic_alterations" is also questionable for an RNA-binding protein involved in post-transcriptional regulation.
Raw API responses
solver
{
"reasoning": "HRPA-1 is the C. elegans ortholog of mammalian hnRNP A1, an RNA-binding protein that regulates post-transcriptional gene expression by binding mRNA 3'-UTRs and modulating mRNA stability, splicing, and translation. In the context of aging, hnRNP-family proteins are known to regulate the expression of stress-response and longevity-associated transcripts, including those in the DAF-16/FOXO and heat-shock response pathways, through 3'-UTR interactions. Post-transcriptional regulation of mRNA stability is a key component of proteostasis and stress-response networks that support longevity in C. elegans. Loss of such RNA-binding regulators can impair the proper expression of protective genes, suggesting a pro-longevity role. However, the specific targets of hrpa-1 in C. elegans are not fully characterized, introducing some uncertainty.",
"confidence": 0.52,
"key_pathways": [
"mRNA 3'-UTR post-transcriptional regulation",
"DAF-16/FOXO stress-response pathway",
"RNA splicing and mRNA stability"
],
"mechanism_class": "epigenetic_alterations",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model predicted pro_longevity while the ground truth is anti_longevity. The model's reasoning is generic and speculative, invoking DAF-16/FOXO pathways without specific evidence for hrpa-1. The model correctly identifies hrpa-1 as an RNA-binding protein involved in post-transcriptional regulation, but incorrectly infers a pro-longevity role. In reality, hrpa-1 is anti-longevity, meaning its loss likely extends lifespan. The model's logic (loss of RNA-binding regulators impairs protective gene expression → pro-longevity) is the opposite of what the data shows. The confidence of 0.52 is low but still leans wrong. The mechanism class of \"epigenetic_alterations\" is also questionable for an RNA-binding protein involved in post-transcriptional regulation.",
"failure_mode": "confident_wrong",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}