gpa-5
C. elegans
Guanine nucleotide-binding protein alpha-5 subunit
What the model saw
Gene: gpa-5 Organism: Caenorhabditis elegans Known functions: Guanine nucleotide-binding protein alpha-5 subunit. G protein-coupled receptor binding. G-protein beta/gamma-subunit complex binding. GTPase activity. guanyl nucleotide binding.
View unredacted entry
Guanine nucleotide-binding protein alpha-5 subunit. G protein-coupled receptor binding. G-protein beta/gamma-subunit complex binding. GTPase activity. guanyl nucleotide binding.
Solver output
GPA-5 is a Gα subunit that couples GPCRs to downstream effectors via GTPase cycling. In C. elegans, Gα proteins modulate chemosensory and neuroendocrine signaling, which can feed into insulin/IGF-1-like (IIS) and TGF-β pathways that regulate longevity. However, the specific downstream effectors and whether GPA-5 activates or inhibits pro-longevity pathways (e.g., DAF-16/FOXO activation vs. suppression) cannot be determined from the molecular function annotations alone. Different Gα subunits in C. elegans have opposing effects on lifespan depending on the neuronal context and coupled receptor, making a directional prediction unreliable without additional pathway-specific data.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" while the ground truth is "anti_longevity." The model's reasoning is logically sound given the limited information provided - it correctly identifies GPA-5 as a Gα subunit involved in GPCR signaling and notes that different Gα subunits can have opposing effects on lifespan. However, it failed to commit to a directional prediction. The mechanism class of "deregulated_nutrient_sensing" is plausible but not confirmed. The model's uncertainty was appropriate given the sparse annotations, but it still got the answer wrong. The confidence of 0.38 reflects genuine uncertainty, making this an "appropriately_uncertain" failure rather than a confident wrong answer.
Raw API responses
solver
{
"reasoning": "GPA-5 is a Gα subunit that couples GPCRs to downstream effectors via GTPase cycling. In C. elegans, Gα proteins modulate chemosensory and neuroendocrine signaling, which can feed into insulin/IGF-1-like (IIS) and TGF-β pathways that regulate longevity. However, the specific downstream effectors and whether GPA-5 activates or inhibits pro-longevity pathways (e.g., DAF-16/FOXO activation vs. suppression) cannot be determined from the molecular function annotations alone. Different Gα subunits in C. elegans have opposing effects on lifespan depending on the neuronal context and coupled receptor, making a directional prediction unreliable without additional pathway-specific data.",
"confidence": 0.38,
"key_pathways": [
"GPCR-Gα signaling",
"insulin/IGF-1-like signaling (IIS)",
"neuroendocrine longevity regulation"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" while the ground truth is \"anti_longevity.\" The model's reasoning is logically sound given the limited information provided - it correctly identifies GPA-5 as a Gα subunit involved in GPCR signaling and notes that different Gα subunits can have opposing effects on lifespan. However, it failed to commit to a directional prediction. The mechanism class of \"deregulated_nutrient_sensing\" is plausible but not confirmed. The model's uncertainty was appropriate given the sparse annotations, but it still got the answer wrong. The confidence of 0.38 reflects genuine uncertainty, making this an \"appropriately_uncertain\" failure rather than a confident wrong answer.",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 3,
"ground_truth_questionable": false
}