FBP1
S. cerevisiae
fructose 1,6-bisphosphate 1-phosphatase
What the model saw
Gene: FBP1 Organism: Saccharomyces cerevisiae Known functions: fructose 1,6-bisphosphate 1-phosphatase. fructose 1,6-bisphosphate 1-phosphatase activity. phosphatase activity. phosphoric ester hydrolase activity.
View unredacted entry
fructose 1,6-bisphosphate 1-phosphatase. fructose 1,6-bisphosphate 1-phosphatase activity. phosphatase activity. phosphoric ester hydrolase activity.
Solver output
FBP1 encodes fructose-1,6-bisphosphatase, the key gluconeogenic enzyme that hydrolyzes fructose-1,6-bisphosphate to fructose-6-phosphate, opposing glycolysis. In S. cerevisiae, FBP1 expression is strongly repressed by glucose and induced during caloric restriction or growth on non-fermentable carbon sources. Active gluconeogenesis via FBP1 is a hallmark of low-nutrient/low-glucose signaling states, which are associated with reduced PKA and TOR pathway activity — both of which are pro-longevity when downregulated. By promoting gluconeogenic flux and being upregulated under caloric restriction conditions, FBP1 activity is functionally coupled to the nutrient-sensing axis that extends lifespan. Loss of FBP1 would impair the metabolic shift away from fermentation, effectively mimicking a high-glucose/high-nutrient state that shortens lifespan.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted pro_longevity but the ground truth is anti_longevity. The model's reasoning is plausible-sounding but ultimately incorrect. While FBP1 is indeed upregulated under caloric restriction conditions, the model incorrectly infers that this makes it pro-longevity. In reality, FBP1 is anti-longevity in yeast. The model's logic — that FBP1 upregulation under CR conditions means it promotes longevity — is a correlation/causation error. The model was fairly confident (0.72) in its wrong answer. The mechanistic reasoning about gluconeogenesis and nutrient sensing is partially correct in describing FBP1's biochemical role, but the conclusion about its longevity effect is wrong.
Raw API responses
solver
{
"reasoning": "FBP1 encodes fructose-1,6-bisphosphatase, the key gluconeogenic enzyme that hydrolyzes fructose-1,6-bisphosphate to fructose-6-phosphate, opposing glycolysis. In S. cerevisiae, FBP1 expression is strongly repressed by glucose and induced during caloric restriction or growth on non-fermentable carbon sources. Active gluconeogenesis via FBP1 is a hallmark of low-nutrient/low-glucose signaling states, which are associated with reduced PKA and TOR pathway activity — both of which are pro-longevity when downregulated. By promoting gluconeogenic flux and being upregulated under caloric restriction conditions, FBP1 activity is functionally coupled to the nutrient-sensing axis that extends lifespan. Loss of FBP1 would impair the metabolic shift away from fermentation, effectively mimicking a high-glucose/high-nutrient state that shortens lifespan.",
"confidence": 0.72,
"key_pathways": [
"gluconeogenesis / fructose-1,6-bisphosphatase activity",
"TOR/PKA nutrient sensing pathway",
"caloric restriction metabolic reprogramming"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model predicted pro_longevity but the ground truth is anti_longevity. The model's reasoning is plausible-sounding but ultimately incorrect. While FBP1 is indeed upregulated under caloric restriction conditions, the model incorrectly infers that this makes it pro-longevity. In reality, FBP1 is anti-longevity in yeast. The model's logic — that FBP1 upregulation under CR conditions means it promotes longevity — is a correlation/causation error. The model was fairly confident (0.72) in its wrong answer. The mechanistic reasoning about gluconeogenesis and nutrient sensing is partially correct in describing FBP1's biochemical role, but the conclusion about its longevity effect is wrong.",
"failure_mode": "confident_wrong",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}