cbp-3
C. elegans
histone acetyltransferase
What the model saw
Gene: cbp-3 Organism: Caenorhabditis elegans Known functions: histone acetyltransferase. histone acetyltransferase activity. protein-lysine-acetyltransferase activity.
View unredacted entry
histone acetyltransferase. histone acetyltransferase activity. protein-lysine-acetyltransferase activity.
Solver output
cbp-3 encodes a histone acetyltransferase (HAT) in C. elegans, orthologous to the CBP/p300 family of transcriptional coactivators. HATs like CBP/p300 acetylate histone lysine residues (e.g., H3K27ac, H3K18ac), opening chromatin and enabling transcription of stress-response and longevity-associated genes. In C. elegans, CBP-1 (the primary CBP ortholog) is known to cooperate with DAF-16/FOXO to promote longevity downstream of the insulin/IGF-1 signaling pathway; cbp-3, as a related HAT, likely participates in similar epigenetic activation of pro-longevity transcriptional programs. Maintenance of appropriate histone acetylation patterns is critical to counteract age-associated epigenetic drift and heterochromatin loss. Loss of HAT activity in aging organisms is associated with transcriptional silencing of stress-response genes, supporting a pro-longevity role for cbp-3's normal function.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted pro_longevity for cbp-3. The mechanistic reasoning is plausible and grounded in known C. elegans biology (CBP/p300 family HATs, DAF-16/FOXO cooperation, epigenetic regulation of longevity). However, the reasoning is somewhat speculative - the model explicitly notes cbp-3 is a "related" HAT to CBP-1 and uses hedged language ("likely participates"), suggesting it's extrapolating from CBP-1 rather than citing direct evidence for cbp-3 specifically. The confidence of 0.65 is appropriately modest given this uncertainty. Overall a reasonable prediction with sound mechanistic logic, though not strongly evidence-based for cbp-3 specifically.
Raw API responses
solver
{
"reasoning": "cbp-3 encodes a histone acetyltransferase (HAT) in C. elegans, orthologous to the CBP/p300 family of transcriptional coactivators. HATs like CBP/p300 acetylate histone lysine residues (e.g., H3K27ac, H3K18ac), opening chromatin and enabling transcription of stress-response and longevity-associated genes. In C. elegans, CBP-1 (the primary CBP ortholog) is known to cooperate with DAF-16/FOXO to promote longevity downstream of the insulin/IGF-1 signaling pathway; cbp-3, as a related HAT, likely participates in similar epigenetic activation of pro-longevity transcriptional programs. Maintenance of appropriate histone acetylation patterns is critical to counteract age-associated epigenetic drift and heterochromatin loss. Loss of HAT activity in aging organisms is associated with transcriptional silencing of stress-response genes, supporting a pro-longevity role for cbp-3's normal function.",
"confidence": 0.65,
"key_pathways": [
"histone acetylation / chromatin remodeling",
"DAF-16/FOXO transcriptional activation",
"insulin/IGF-1 longevity signaling"
],
"mechanism_class": "epigenetic_alterations",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model correctly predicted pro_longevity for cbp-3. The mechanistic reasoning is plausible and grounded in known C. elegans biology (CBP/p300 family HATs, DAF-16/FOXO cooperation, epigenetic regulation of longevity). However, the reasoning is somewhat speculative - the model explicitly notes cbp-3 is a \"related\" HAT to CBP-1 and uses hedged language (\"likely participates\"), suggesting it's extrapolating from CBP-1 rather than citing direct evidence for cbp-3 specifically. The confidence of 0.65 is appropriately modest given this uncertainty. Overall a reasonable prediction with sound mechanistic logic, though not strongly evidence-based for cbp-3 specifically.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 3,
"ground_truth_questionable": false
}