IMG1
S. cerevisiae
mitochondrial 54S ribosomal protein bL19m IMG1
What the model saw
Gene: IMG1 Organism: Saccharomyces cerevisiae Known functions: mitochondrial 54S ribosomal protein bL19m IMG1. structural constituent of ribosome.
View unredacted entry
mitochondrial 54S ribosomal protein bL19m IMG1. structural constituent of ribosome.
Solver output
IMG1 encodes the mitochondrial large ribosomal subunit protein bL19m, a structural constituent of the 54S (mt-LSU) ribosome in yeast. Its primary role is to support mitochondrial translation, which is essential for the synthesis of oxidative phosphorylation (OXPHOS) complex subunits encoded by the mitochondrial genome. Intact mitochondrial translation is required for maintaining respiratory capacity and mitochondrial membrane potential, both of which are critical for healthy aging in yeast. Loss of mitochondrial ribosomal function leads to petite formation, loss of mtDNA integrity, and impaired OXPHOS, which are associated with accelerated aging and reduced chronological/replicative lifespan. Therefore, the normal function of IMG1 supports mitochondrial proteostasis and bioenergetics, promoting longevity rather than opposing it.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted pro_longevity but the ground truth is anti_longevity. The model's reasoning follows a plausible but incorrect logic: it assumes that because IMG1 supports mitochondrial translation and OXPHOS, its normal function must promote longevity. However, the GenAge database classifies IMG1 as anti_longevity, meaning its deletion or loss actually extends lifespan. This is consistent with findings in yeast where deletion of certain mitochondrial ribosomal proteins can extend replicative or chronological lifespan, possibly through mechanisms like mitohormesis or reduced OXPHOS-associated ROS production. The model's mechanistic reasoning about mitochondrial translation being essential for healthy aging is not wrong in general terms, but it fails to account for the specific experimental evidence showing IMG1 is anti-longevity. The model was moderately confident (0.62) in the wrong direction.
Raw API responses
solver
{
"reasoning": "IMG1 encodes the mitochondrial large ribosomal subunit protein bL19m, a structural constituent of the 54S (mt-LSU) ribosome in yeast. Its primary role is to support mitochondrial translation, which is essential for the synthesis of oxidative phosphorylation (OXPHOS) complex subunits encoded by the mitochondrial genome. Intact mitochondrial translation is required for maintaining respiratory capacity and mitochondrial membrane potential, both of which are critical for healthy aging in yeast. Loss of mitochondrial ribosomal function leads to petite formation, loss of mtDNA integrity, and impaired OXPHOS, which are associated with accelerated aging and reduced chronological/replicative lifespan. Therefore, the normal function of IMG1 supports mitochondrial proteostasis and bioenergetics, promoting longevity rather than opposing it.",
"confidence": 0.62,
"key_pathways": [
"mitochondrial translation / 54S ribosome assembly",
"oxidative phosphorylation (OXPHOS)",
"mitochondrial genome maintenance"
],
"mechanism_class": "mitochondrial_dysfunction",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model predicted pro_longevity but the ground truth is anti_longevity. The model's reasoning follows a plausible but incorrect logic: it assumes that because IMG1 supports mitochondrial translation and OXPHOS, its normal function must promote longevity. However, the GenAge database classifies IMG1 as anti_longevity, meaning its deletion or loss actually extends lifespan. This is consistent with findings in yeast where deletion of certain mitochondrial ribosomal proteins can extend replicative or chronological lifespan, possibly through mechanisms like mitohormesis or reduced OXPHOS-associated ROS production. The model's mechanistic reasoning about mitochondrial translation being essential for healthy aging is not wrong in general terms, but it fails to account for the specific experimental evidence showing IMG1 is anti-longevity. The model was moderately confident (0.62) in the wrong direction.",
"failure_mode": "confident_wrong",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}