argk-1
C. elegans
arginine kinase
What the model saw
Gene: argk-1 Organism: Caenorhabditis elegans Known functions: arginine kinase. ATP binding. arginine kinase activity. catalytic activity. kinase activity. phosphotransferase activity, nitrogenous group as acceptor. transferase activity, transferring phosphorus-containing groups.
View unredacted entry
arginine kinase. ATP binding. arginine kinase activity. catalytic activity. kinase activity. phosphotransferase activity, nitrogenous group as acceptor. transferase activity, transferring phosphorus-containing groups.
Solver output
Arginine kinase (ARGK-1) catalyzes the reversible transfer of a phosphoryl group from ATP to arginine, generating phosphoarginine, which serves as a rapidly mobilizable phosphagen energy buffer in invertebrates — the functional analog of creatine kinase/phosphocreatine in vertebrates. This phosphagen system maintains ATP homeostasis during periods of high energy demand or metabolic stress. Robust cellular energy buffering supports mitochondrial efficiency and metabolic resilience, both of which are associated with extended lifespan in C. elegans. Loss of phosphagen buffering capacity leads to energetic imbalance and accelerated aging phenotypes, while its maintenance is linked to healthspan. The pathway intersects with nutrient/energy sensing networks (AMPK signaling) because phosphoarginine/ATP ratios influence AMP:ATP balance, a key input to AMPK, a known pro-longevity kinase in C. elegans.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted pro_longevity for argk-1. The mechanistic reasoning is well-grounded: arginine kinase as a phosphagen energy buffer in invertebrates, its role in ATP homeostasis, and the connection to AMPK signaling are all plausible and scientifically sound. The mechanism class "deregulated_nutrient_sensing" is a reasonable (if slightly imprecise) categorization given the AMPK connection. The confidence of 0.62 is appropriately moderate. Overall a solid prediction with good mechanistic reasoning.
Raw API responses
solver
{
"reasoning": "Arginine kinase (ARGK-1) catalyzes the reversible transfer of a phosphoryl group from ATP to arginine, generating phosphoarginine, which serves as a rapidly mobilizable phosphagen energy buffer in invertebrates — the functional analog of creatine kinase/phosphocreatine in vertebrates. This phosphagen system maintains ATP homeostasis during periods of high energy demand or metabolic stress. Robust cellular energy buffering supports mitochondrial efficiency and metabolic resilience, both of which are associated with extended lifespan in C. elegans. Loss of phosphagen buffering capacity leads to energetic imbalance and accelerated aging phenotypes, while its maintenance is linked to healthspan. The pathway intersects with nutrient/energy sensing networks (AMPK signaling) because phosphoarginine/ATP ratios influence AMP:ATP balance, a key input to AMPK, a known pro-longevity kinase in C. elegans.",
"confidence": 0.62,
"key_pathways": [
"phosphagen energy buffering (phosphoarginine system)",
"AMPK energy sensing pathway",
"cellular ATP homeostasis"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model correctly predicted pro_longevity for argk-1. The mechanistic reasoning is well-grounded: arginine kinase as a phosphagen energy buffer in invertebrates, its role in ATP homeostasis, and the connection to AMPK signaling are all plausible and scientifically sound. The mechanism class \"deregulated_nutrient_sensing\" is a reasonable (if slightly imprecise) categorization given the AMPK connection. The confidence of 0.62 is appropriately moderate. Overall a solid prediction with good mechanistic reasoning.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 4,
"ground_truth_questionable": false
}