5-ht2a
D. melanogaster
5-hydroxytryptamine (serotonin) receptor 2A
What the model saw
Gene: 5-HT2A Organism: Drosophila melanogaster Known functions: 5-hydroxytryptamine (serotonin) receptor 2A. G protein-coupled amine receptor activity. G protein-coupled receptor activity. G protein-coupled serotonin receptor activity. Gq/11-coupled serotonin receptor activity. neurotransmitter receptor activity. serotonin binding.
View unredacted entry
5-hydroxytryptamine (serotonin) receptor 2A. G protein-coupled amine receptor activity. G protein-coupled receptor activity. G protein-coupled serotonin receptor activity. Gq/11-coupled serotonin receptor activity. neurotransmitter receptor activity. serotonin binding.
Solver output
The 5-HT2A receptor is a Gq/11-coupled serotonin receptor that activates phospholipase C and downstream PKC/IP3 signaling upon serotonin binding. In Drosophila, serotonergic signaling intersects with nutrient-sensing pathways including insulin/IGF-1 signaling (IIS) and TOR, where serotonin can modulate feeding behavior and metabolic homeostasis. Gq/11-coupled receptor activation in the gut and nervous system influences nutrient sensing and energy allocation, processes tightly linked to longevity regulation. Serotonin signaling through 5-HT2A-type receptors has been associated with dietary restriction-like effects and modulation of IIS activity in invertebrates, which can extend lifespan. However, the net effect is context-dependent, as excessive Gq/11 signaling can also promote cellular stress, making this prediction moderately confident.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted pro_longevity while the ground truth is anti_longevity. The model's reasoning is speculative and not well-grounded in specific Drosophila 5-HT2A literature. It invokes general serotonin/nutrient-sensing connections and "dietary restriction-like effects" without solid mechanistic basis. The mechanism class (deregulated_nutrient_sensing) is also likely incorrect - 5-HT2A as an anti-longevity gene in Drosophila is more likely related to direct serotonergic signaling effects rather than nutrient sensing per se. The model acknowledged context-dependence but still chose the wrong direction. Confidence of 0.55 is relatively low but still committed to the wrong answer.
Raw API responses
solver
{
"reasoning": "The 5-HT2A receptor is a Gq/11-coupled serotonin receptor that activates phospholipase C and downstream PKC/IP3 signaling upon serotonin binding. In Drosophila, serotonergic signaling intersects with nutrient-sensing pathways including insulin/IGF-1 signaling (IIS) and TOR, where serotonin can modulate feeding behavior and metabolic homeostasis. Gq/11-coupled receptor activation in the gut and nervous system influences nutrient sensing and energy allocation, processes tightly linked to longevity regulation. Serotonin signaling through 5-HT2A-type receptors has been associated with dietary restriction-like effects and modulation of IIS activity in invertebrates, which can extend lifespan. However, the net effect is context-dependent, as excessive Gq/11 signaling can also promote cellular stress, making this prediction moderately confident.",
"confidence": 0.55,
"key_pathways": [
"Gq/11-PLC-PKC serotonin signaling",
"insulin/IGF-1 nutrient sensing pathway",
"serotonin-mediated feeding and metabolic regulation"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model predicted pro_longevity while the ground truth is anti_longevity. The model's reasoning is speculative and not well-grounded in specific Drosophila 5-HT2A literature. It invokes general serotonin/nutrient-sensing connections and \"dietary restriction-like effects\" without solid mechanistic basis. The mechanism class (deregulated_nutrient_sensing) is also likely incorrect - 5-HT2A as an anti-longevity gene in Drosophila is more likely related to direct serotonergic signaling effects rather than nutrient sensing per se. The model acknowledged context-dependence but still chose the wrong direction. Confidence of 0.55 is relatively low but still committed to the wrong answer.",
"failure_mode": "confident_wrong",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}