raga-1
C. elegans
GTP-binding protein
What the model saw
Gene: raga-1 Organism: Caenorhabditis elegans Known functions: GTP-binding protein. GTP binding. GTPase activity.
View unredacted entry
GTP-binding protein. GTP binding. GTPase activity.
Solver output
raga-1 is the C. elegans ortholog of RagA (RRAGA in mammals), a Ras-family GTPase that forms a heterodimer with RagC/D to sense amino acid availability and recruit mTORC1 to the lysosomal surface for activation. In its GTP-bound (active) state, RagA activates TORC1 signaling, which suppresses autophagy, inhibits stress-response transcription factors (e.g., DAF-16/FOXO, PHA-4/FOXA), and promotes anabolic growth. Elevated TORC1 activity via raga-1 is well-established to shorten lifespan in C. elegans, while loss-of-function mutations in raga-1 extend lifespan by reducing TORC1 activity. This places raga-1 squarely in the nutrient-sensing (TOR) pathway as a pro-aging factor, opposing longevity under normal function.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly identified raga-1 as anti_longevity with high confidence (0.88). The mechanistic reasoning is excellent and accurate: raga-1 encodes the C. elegans RagA GTPase ortholog that activates TORC1 signaling in response to amino acid availability, promoting aging. Loss-of-function mutations extend lifespan by reducing TORC1 activity. The model correctly identifies the key pathways involved (TORC1, Rag GTPase, DAF-16/FOXO) and accurately describes the molecular mechanism. This is a well-supported prediction with correct reasoning.
Raw API responses
solver
{
"reasoning": "raga-1 is the C. elegans ortholog of RagA (RRAGA in mammals), a Ras-family GTPase that forms a heterodimer with RagC/D to sense amino acid availability and recruit mTORC1 to the lysosomal surface for activation. In its GTP-bound (active) state, RagA activates TORC1 signaling, which suppresses autophagy, inhibits stress-response transcription factors (e.g., DAF-16/FOXO, PHA-4/FOXA), and promotes anabolic growth. Elevated TORC1 activity via raga-1 is well-established to shorten lifespan in C. elegans, while loss-of-function mutations in raga-1 extend lifespan by reducing TORC1 activity. This places raga-1 squarely in the nutrient-sensing (TOR) pathway as a pro-aging factor, opposing longevity under normal function.",
"confidence": 0.88,
"key_pathways": [
"mTORC1/TORC1 nutrient sensing",
"Rag GTPase amino acid signaling",
"DAF-16/FOXO longevity pathway"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "anti_longevity"
}advisor
{
"notes": "The model correctly identified raga-1 as anti_longevity with high confidence (0.88). The mechanistic reasoning is excellent and accurate: raga-1 encodes the C. elegans RagA GTPase ortholog that activates TORC1 signaling in response to amino acid availability, promoting aging. Loss-of-function mutations extend lifespan by reducing TORC1 activity. The model correctly identifies the key pathways involved (TORC1, Rag GTPase, DAF-16/FOXO) and accurately describes the molecular mechanism. This is a well-supported prediction with correct reasoning.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 5,
"ground_truth_questionable": false
}