odr-7
C. elegans
Nuclear hormone receptor family member odr-7
What the model saw
Gene: odr-7 Organism: Caenorhabditis elegans Known functions: Nuclear hormone receptor family member odr-7. DNA binding. DNA-binding transcription activator activity, RNA polymerase II-specific. DNA-binding transcription factor activity. RNA polymerase II cis-regulatory region sequence-specific DNA binding. nuclear receptor activity. sequence-specific DNA binding. zinc ion binding.
View unredacted entry
Nuclear hormone receptor family member odr-7. DNA binding. DNA-binding transcription activator activity, RNA polymerase II-specific. DNA-binding transcription factor activity. RNA polymerase II cis-regulatory region sequence-specific DNA binding. nuclear receptor activity. sequence-specific DNA binding. zinc ion binding.
Solver output
ODR-7 is a nuclear hormone receptor (NHR) family transcription factor in C. elegans, functioning as a sequence-specific DNA-binding transcriptional activator via RNA Pol II. Nuclear hormone receptors in C. elegans (the NHR superfamily) are broadly linked to metabolic and nutrient-sensing regulation, analogous to roles played by DAF-12 and other NHRs in the insulin/IGF-1 and steroid hormone signaling axes. However, odr-7 is specifically expressed in the AWA olfactory neuron and primarily governs chemosensory neuron identity and odorant receptor gene expression, rather than directly modulating canonical longevity pathways such as DAF-16/FOXO or DAF-12 sterol signaling. Its transcriptional activator role in a sensory neuron context does not map cleanly to a pro- or anti-longevity mechanism, as chemosensory neuron ablation studies show complex, context-dependent effects on lifespan. The zinc ion binding and nuclear receptor activity are consistent with ligand-regulated transcription, but no clear longevity-relevant ligand or downstream target has been established for odr-7 specifically.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" while the ground truth is "anti_longevity." The model's reasoning is actually quite good - it correctly identifies odr-7 as an AWA olfactory neuron transcription factor involved in chemosensory neuron identity, and notes that chemosensory neuron ablation studies show complex effects on lifespan. However, it failed to commit to the anti-longevity classification. The model's mechanism class of "deregulated_nutrient_sensing" is not well-supported by the reasoning provided (the model itself says odr-7 doesn't directly modulate canonical longevity pathways). The connection between odr-7's role in chemosensory neurons and anti-longevity is likely through the known finding that ablation of AWA neurons (which odr-7 specifies) extends lifespan, meaning odr-7 activity promotes normal AWA function which has a net anti-longevity effect. The model was appropriately uncertain given the indirect nature of the connection, but ultimately got the answer wrong. Confidence of 0.35 reflects appropriate uncertainty.
Raw API responses
solver
{
"reasoning": "ODR-7 is a nuclear hormone receptor (NHR) family transcription factor in C. elegans, functioning as a sequence-specific DNA-binding transcriptional activator via RNA Pol II. Nuclear hormone receptors in C. elegans (the NHR superfamily) are broadly linked to metabolic and nutrient-sensing regulation, analogous to roles played by DAF-12 and other NHRs in the insulin/IGF-1 and steroid hormone signaling axes. However, odr-7 is specifically expressed in the AWA olfactory neuron and primarily governs chemosensory neuron identity and odorant receptor gene expression, rather than directly modulating canonical longevity pathways such as DAF-16/FOXO or DAF-12 sterol signaling. Its transcriptional activator role in a sensory neuron context does not map cleanly to a pro- or anti-longevity mechanism, as chemosensory neuron ablation studies show complex, context-dependent effects on lifespan. The zinc ion binding and nuclear receptor activity are consistent with ligand-regulated transcription, but no clear longevity-relevant ligand or downstream target has been established for odr-7 specifically.",
"confidence": 0.35,
"key_pathways": [
"nuclear hormone receptor signaling",
"chemosensory neuron identity specification",
"RNA polymerase II transcriptional activation"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" while the ground truth is \"anti_longevity.\" The model's reasoning is actually quite good - it correctly identifies odr-7 as an AWA olfactory neuron transcription factor involved in chemosensory neuron identity, and notes that chemosensory neuron ablation studies show complex effects on lifespan. However, it failed to commit to the anti-longevity classification. The model's mechanism class of \"deregulated_nutrient_sensing\" is not well-supported by the reasoning provided (the model itself says odr-7 doesn't directly modulate canonical longevity pathways). The connection between odr-7's role in chemosensory neurons and anti-longevity is likely through the known finding that ablation of AWA neurons (which odr-7 specifies) extends lifespan, meaning odr-7 activity promotes normal AWA function which has a net anti-longevity effect. The model was appropriately uncertain given the indirect nature of the connection, but ultimately got the answer wrong. Confidence of 0.35 reflects appropriate uncertainty.",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 3,
"ground_truth_questionable": false
}