tcer-1
C. elegans
Transcription elongation regulator 1;WW domain-containing protein
What the model saw
Gene: tcer-1 Organism: Caenorhabditis elegans Known functions: Transcription elongation regulator 1;WW domain-containing protein. RNA polymerase binding. transcription coregulator activity.
View unredacted entry
Transcription elongation regulator 1;WW domain-containing protein. RNA polymerase binding. transcription coregulator activity.
Solver output
tcer-1 encodes the C. elegans ortholog of Transcription Elongation Regulator 1 (TCERG1/CA150), a WW domain-containing protein that binds RNA polymerase II and acts as a transcription coregulator controlling elongation efficiency. In C. elegans, tcer-1 has been experimentally shown to be a key downstream effector of the germline-to-soma longevity signaling pathway: loss of the germline extends lifespan in a tcer-1-dependent manner, and tcer-1 overexpression itself extends lifespan. By modulating RNA Pol II elongation, tcer-1 regulates the transcriptional output of longevity-promoting transcription factors (including DAF-16/FOXO and PHA-4/FOXA), thereby amplifying the expression of stress-resistance and metabolic genes that promote healthy aging. This positions tcer-1 as a pro-longevity transcriptional coactivator whose normal function enhances the epigenetic/transcriptional programs that extend lifespan.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted tcer-1 as pro_longevity with high confidence (0.82). The mechanistic reasoning is accurate and detailed: tcer-1 is indeed a key downstream effector of germline longevity signaling in C. elegans, its overexpression extends lifespan, and it works through DAF-16/FOXO and PHA-4/FOXA transcriptional axes. The mechanism class of "epigenetic_alterations" is a reasonable categorization for transcriptional regulation, though "transcriptional regulation" might be more precise. The key pathways identified are all correct and well-supported by the literature. Overall, this is an excellent prediction with accurate mechanistic reasoning.
Raw API responses
solver
{
"reasoning": "tcer-1 encodes the C. elegans ortholog of Transcription Elongation Regulator 1 (TCERG1/CA150), a WW domain-containing protein that binds RNA polymerase II and acts as a transcription coregulator controlling elongation efficiency. In C. elegans, tcer-1 has been experimentally shown to be a key downstream effector of the germline-to-soma longevity signaling pathway: loss of the germline extends lifespan in a tcer-1-dependent manner, and tcer-1 overexpression itself extends lifespan. By modulating RNA Pol II elongation, tcer-1 regulates the transcriptional output of longevity-promoting transcription factors (including DAF-16/FOXO and PHA-4/FOXA), thereby amplifying the expression of stress-resistance and metabolic genes that promote healthy aging. This positions tcer-1 as a pro-longevity transcriptional coactivator whose normal function enhances the epigenetic/transcriptional programs that extend lifespan.",
"confidence": 0.82,
"key_pathways": [
"germline longevity signaling / DAF-16 transcriptional axis",
"RNA Pol II transcription elongation regulation",
"PHA-4/FOXA transcriptional coactivation"
],
"mechanism_class": "epigenetic_alterations",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model correctly predicted tcer-1 as pro_longevity with high confidence (0.82). The mechanistic reasoning is accurate and detailed: tcer-1 is indeed a key downstream effector of germline longevity signaling in C. elegans, its overexpression extends lifespan, and it works through DAF-16/FOXO and PHA-4/FOXA transcriptional axes. The mechanism class of \"epigenetic_alterations\" is a reasonable categorization for transcriptional regulation, though \"transcriptional regulation\" might be more precise. The key pathways identified are all correct and well-supported by the literature. Overall, this is an excellent prediction with accurate mechanistic reasoning.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 5,
"ground_truth_questionable": false
}