sck2
S. pombe
serine/threonine protein kinase S6K family Sck2
What the model saw
Gene: sck2 Organism: Schizosaccharomyces pombe Known functions: serine/threonine protein kinase S6K family Sck2. ATP binding. protein kinase activity. protein serine kinase activity. protein serine/threonine kinase activity.
View unredacted entry
serine/threonine protein kinase S6K family Sck2. ATP binding. protein kinase activity. protein serine kinase activity. protein serine/threonine kinase activity.
Solver output
Sck2 is the S. pombe ortholog of mammalian S6 kinase (S6K), a key downstream effector of the TORC1 (Target of Rapamycin Complex 1) nutrient-sensing pathway. In the TOR signaling axis, S6K activity promotes anabolic processes (protein synthesis, cell growth) and suppresses autophagy. Hyperactivation of S6K/TOR signaling is a well-established driver of accelerated aging across model organisms, while its reduction — through rapamycin treatment, dietary restriction, or genetic loss-of-function — consistently extends lifespan. Sck2's serine/threonine kinase activity phosphorylates ribosomal protein S6 and other translational regulators, boosting protein synthesis at the expense of stress resistance and longevity. Loss of sck2 in S. pombe has been shown to extend chronological lifespan, consistent with its role as a pro-aging TOR effector. Therefore, the normal function of Sck2 opposes longevity by sustaining TOR-S6K anabolic signaling and suppressing the pro-longevity effects of nutrient limitation.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted anti_longevity for sck2 in S. pombe with high confidence (0.85). The mechanistic reasoning is thorough and accurate: sck2 encodes an S6K family kinase downstream of TORC1, and its deletion extends chronological lifespan in S. pombe. The model correctly identifies the TOR/S6K nutrient-sensing axis, the role in promoting anabolic processes and suppressing autophagy, and the conservation of this pro-aging role across organisms. All key pathways identified are relevant and correct.
Raw API responses
solver
{
"reasoning": "Sck2 is the S. pombe ortholog of mammalian S6 kinase (S6K), a key downstream effector of the TORC1 (Target of Rapamycin Complex 1) nutrient-sensing pathway. In the TOR signaling axis, S6K activity promotes anabolic processes (protein synthesis, cell growth) and suppresses autophagy. Hyperactivation of S6K/TOR signaling is a well-established driver of accelerated aging across model organisms, while its reduction — through rapamycin treatment, dietary restriction, or genetic loss-of-function — consistently extends lifespan. Sck2's serine/threonine kinase activity phosphorylates ribosomal protein S6 and other translational regulators, boosting protein synthesis at the expense of stress resistance and longevity. Loss of sck2 in S. pombe has been shown to extend chronological lifespan, consistent with its role as a pro-aging TOR effector. Therefore, the normal function of Sck2 opposes longevity by sustaining TOR-S6K anabolic signaling and suppressing the pro-longevity effects of nutrient limitation.",
"confidence": 0.85,
"key_pathways": [
"TOR/TORC1 signaling",
"S6 kinase-mediated translational control",
"nutrient sensing and autophagy suppression"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "anti_longevity"
}advisor
{
"notes": "The model correctly predicted anti_longevity for sck2 in S. pombe with high confidence (0.85). The mechanistic reasoning is thorough and accurate: sck2 encodes an S6K family kinase downstream of TORC1, and its deletion extends chronological lifespan in S. pombe. The model correctly identifies the TOR/S6K nutrient-sensing axis, the role in promoting anabolic processes and suppressing autophagy, and the conservation of this pro-aging role across organisms. All key pathways identified are relevant and correct.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 5,
"ground_truth_questionable": false
}