kra
D. melanogaster
krasavietz
What the model saw
Gene: kra Organism: Drosophila melanogaster Known functions: krasavietz. protein binding. ribosomal small subunit binding. ribosome binding. translation initiation factor binding.
View unredacted entry
krasavietz. protein binding. ribosomal small subunit binding. ribosome binding. translation initiation factor binding.
Solver output
The krasavietz (kra) protein binds the ribosomal small subunit and translation initiation factors, placing it as a regulator of translational initiation. In the context of aging, reduced or fine-tuned translational output — particularly through modulation of ribosome activity and initiation factor interactions — is a well-established pro-longevity mechanism in model organisms including Drosophila. By binding and potentially inhibiting or modulating translation initiation factor activity at the small ribosomal subunit, kra may act as a translational brake, reducing global protein synthesis rates and thereby alleviating proteostatic stress. Reduced translation rates are linked to decreased mTORC1 signaling output and improved proteostasis, both of which extend lifespan. This places kra's function in the proteostasis/translational regulation axis of aging, analogous to roles described for other ribosome-associated regulatory proteins in longevity pathways.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted pro_longevity but the ground truth is anti_longevity. The model's reasoning was plausible-sounding but ultimately incorrect — it assumed kra acts as a "translational brake" that reduces protein synthesis and thereby extends lifespan, but the actual evidence indicates kra is anti-longevity (i.e., its presence shortens lifespan or its loss extends it). The mechanistic reasoning was speculative and built on a general heuristic (reduced translation = longer life) without specific evidence for kra's actual role. The model had moderate confidence (0.62) but was wrong on both the direction and the mechanism.
Raw API responses
solver
{
"reasoning": "The krasavietz (kra) protein binds the ribosomal small subunit and translation initiation factors, placing it as a regulator of translational initiation. In the context of aging, reduced or fine-tuned translational output — particularly through modulation of ribosome activity and initiation factor interactions — is a well-established pro-longevity mechanism in model organisms including Drosophila. By binding and potentially inhibiting or modulating translation initiation factor activity at the small ribosomal subunit, kra may act as a translational brake, reducing global protein synthesis rates and thereby alleviating proteostatic stress. Reduced translation rates are linked to decreased mTORC1 signaling output and improved proteostasis, both of which extend lifespan. This places kra's function in the proteostasis/translational regulation axis of aging, analogous to roles described for other ribosome-associated regulatory proteins in longevity pathways.",
"confidence": 0.62,
"key_pathways": [
"translational initiation regulation",
"ribosome small subunit assembly/binding",
"proteostasis via mTOR-translation axis"
],
"mechanism_class": "loss_of_proteostasis",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model predicted pro_longevity but the ground truth is anti_longevity. The model's reasoning was plausible-sounding but ultimately incorrect — it assumed kra acts as a \"translational brake\" that reduces protein synthesis and thereby extends lifespan, but the actual evidence indicates kra is anti-longevity (i.e., its presence shortens lifespan or its loss extends it). The mechanistic reasoning was speculative and built on a general heuristic (reduced translation = longer life) without specific evidence for kra's actual role. The model had moderate confidence (0.62) but was wrong on both the direction and the mechanism.",
"failure_mode": "confident_wrong",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}