babo
D. melanogaster
baboon
What the model saw
Gene: babo Organism: Drosophila melanogaster Known functions: baboon. ATP binding. activin binding. activin receptor activity. activin receptor activity, type I. protein binding. protein kinase activity. transmembrane receptor protein serine/threonine kinase activity.
View unredacted entry
baboon. ATP binding. activin binding. activin receptor activity. activin receptor activity, type I. protein binding. protein kinase activity. transmembrane receptor protein serine/threonine kinase activity.
Solver output
Baboon (babo) is the Drosophila type I activin receptor (ortholog of mammalian ALK4/5/7) that mediates activin/TGF-β signaling via serine/threonine kinase activity. In Drosophila, activin signaling through Babo activates Smad2/dSmad2 (Smox), which has been shown to promote insulin-like peptide (dILP) production and enhance insulin/IGF signaling (IIS) in the brain. Elevated IIS is a well-established driver of reduced lifespan across model organisms, including Drosophila, by suppressing FOXO transcription factor activity and downstream stress-resistance and autophagy programs. Loss-of-function of babo or its ligands (e.g., Dawdle) extends lifespan in flies, consistent with the receptor's normal function being pro-growth and anti-longevity. Thus, babo's normal activity promotes IIS and growth signaling, opposing longevity.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted anti_longevity for babo. The mechanistic reasoning is detailed and accurate: babo encodes the Drosophila type I activin receptor, which mediates activin/TGF-β signaling, promotes insulin-like peptide production, enhances IIS, and suppresses FOXO activity. The model correctly notes that loss-of-function of babo extends lifespan. The mechanism class "deregulated_nutrient_sensing" is a reasonable categorization given the connection to IIS. The confidence of 0.72 is appropriate. Overall, this is an excellent prediction with solid mechanistic reasoning.
Raw API responses
solver
{
"reasoning": "Baboon (babo) is the Drosophila type I activin receptor (ortholog of mammalian ALK4/5/7) that mediates activin/TGF-β signaling via serine/threonine kinase activity. In Drosophila, activin signaling through Babo activates Smad2/dSmad2 (Smox), which has been shown to promote insulin-like peptide (dILP) production and enhance insulin/IGF signaling (IIS) in the brain. Elevated IIS is a well-established driver of reduced lifespan across model organisms, including Drosophila, by suppressing FOXO transcription factor activity and downstream stress-resistance and autophagy programs. Loss-of-function of babo or its ligands (e.g., Dawdle) extends lifespan in flies, consistent with the receptor's normal function being pro-growth and anti-longevity. Thus, babo's normal activity promotes IIS and growth signaling, opposing longevity.",
"confidence": 0.72,
"key_pathways": [
"Activin/TGF-β signaling",
"Insulin/IGF signaling (IIS)",
"FOXO transcription factor regulation"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "anti_longevity"
}advisor
{
"notes": "The model correctly predicted anti_longevity for babo. The mechanistic reasoning is detailed and accurate: babo encodes the Drosophila type I activin receptor, which mediates activin/TGF-β signaling, promotes insulin-like peptide production, enhances IIS, and suppresses FOXO activity. The model correctly notes that loss-of-function of babo extends lifespan. The mechanism class \"deregulated_nutrient_sensing\" is a reasonable categorization given the connection to IIS. The confidence of 0.72 is appropriate. Overall, this is an excellent prediction with solid mechanistic reasoning.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 5,
"ground_truth_questionable": false
}