dpp
D. melanogaster
decapentaplegic
What the model saw
Gene: dpp Organism: Drosophila melanogaster Known functions: decapentaplegic. BMP receptor binding. collagen binding. cytokine activity. growth factor activity. heparin binding. morphogen activity. protein binding. protein heterodimerization activity. protein homodimerization activity. receptor ligand activity.
View unredacted entry
decapentaplegic. BMP receptor binding. collagen binding. cytokine activity. growth factor activity. heparin binding. morphogen activity. protein binding. protein heterodimerization activity. protein homodimerization activity. receptor ligand activity.
Solver output
Dpp (Decapentaplegic) is the Drosophila ortholog of BMP2/4 and signals through BMP receptors (Tkv/Sax) to activate the Smad transcription factor Mad. As a secreted morphogen and cytokine with growth factor activity, Dpp mediates systemic intercellular communication that regulates tissue homeostasis, stem cell maintenance, and organ size. In aging Drosophila, Dpp signaling from the niche supports intestinal stem cell (ISC) quiescence and gut homeostasis; loss of appropriate Dpp/BMP signaling in the aging gut leads to ISC hyperproliferation and epithelial dysplasia, a hallmark of shortened lifespan. Its receptor ligand and protein heterodimerization activities are consistent with a paracrine/endocrine role in coordinating tissue-level homeostasis across the organism. Maintenance of Dpp signaling thus opposes age-related tissue deterioration, placing it in the pro-longevity category via the altered intercellular communication hallmark.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted pro_longevity for dpp in Drosophila melanogaster. The mechanistic reasoning is detailed and accurate: Dpp/BMP signaling maintains intestinal stem cell quiescence and gut homeostasis in aging flies, and loss of this signaling leads to ISC hyperproliferation and shortened lifespan. The mechanism class of "altered_intercellular_communication" is appropriate given Dpp's role as a secreted morphogen/cytokine. The key pathways identified (BMP/Dpp-Smad signaling, ISC niche homeostasis, TGF-β superfamily) are all relevant and correct. Confidence of 0.72 is reasonable.
Raw API responses
solver
{
"reasoning": "Dpp (Decapentaplegic) is the Drosophila ortholog of BMP2/4 and signals through BMP receptors (Tkv/Sax) to activate the Smad transcription factor Mad. As a secreted morphogen and cytokine with growth factor activity, Dpp mediates systemic intercellular communication that regulates tissue homeostasis, stem cell maintenance, and organ size. In aging Drosophila, Dpp signaling from the niche supports intestinal stem cell (ISC) quiescence and gut homeostasis; loss of appropriate Dpp/BMP signaling in the aging gut leads to ISC hyperproliferation and epithelial dysplasia, a hallmark of shortened lifespan. Its receptor ligand and protein heterodimerization activities are consistent with a paracrine/endocrine role in coordinating tissue-level homeostasis across the organism. Maintenance of Dpp signaling thus opposes age-related tissue deterioration, placing it in the pro-longevity category via the altered intercellular communication hallmark.",
"confidence": 0.72,
"key_pathways": [
"BMP/Dpp-Smad (Mad) signaling",
"intestinal stem cell niche homeostasis",
"TGF-β superfamily intercellular communication"
],
"mechanism_class": "altered_intercellular_communication",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model correctly predicted pro_longevity for dpp in Drosophila melanogaster. The mechanistic reasoning is detailed and accurate: Dpp/BMP signaling maintains intestinal stem cell quiescence and gut homeostasis in aging flies, and loss of this signaling leads to ISC hyperproliferation and shortened lifespan. The mechanism class of \"altered_intercellular_communication\" is appropriate given Dpp's role as a secreted morphogen/cytokine. The key pathways identified (BMP/Dpp-Smad signaling, ISC niche homeostasis, TGF-β superfamily) are all relevant and correct. Confidence of 0.72 is reasonable.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 5,
"ground_truth_questionable": false
}