RPS10B

solver

{
  "reasoning": "RPS10B encodes a structural component of the 40S ribosomal small subunit (eS10), directly contributing to ribosome biogenesis and translational capacity. In yeast, reduced ribosomal protein gene dosage — including deletion of 40S subunit components — is well-established to extend chronological and replicative lifespan, largely through attenuation of TORC1-driven protein synthesis. Excess ribosomal activity promotes anabolic signaling downstream of TOR/Sch9, which accelerates aging. The structural constituent role of RPS10B in the 40S ribosome means its normal function sustains high translational output, opposing longevity. Additionally, ribosome abundance is a key readout of nutrient-sensing pathway activity (TOR/S6K axis), placing this gene squarely in the deregulated nutrient sensing hallmark. Loss-of-function of paralogous ribosomal protein genes in yeast consistently yields lifespan extension, supporting an anti-longevity classification for the wild-type gene.",
  "confidence": 0.72,
  "key_pathways": [
    "TORC1-S6K translational control",
    "40S ribosome biogenesis",
    "ribosomal protein-mediated nutrient sensing"
  ],
  "mechanism_class": "deregulated_nutrient_sensing",
  "longevity_influence": "anti_longevity"
}

advisor

{
  "notes": "The model correctly predicted anti_longevity for RPS10B. The mechanistic reasoning is sound and well-articulated: RPS10B encodes a 40S ribosomal subunit protein, and deletion of ribosomal protein genes in yeast is well-established to extend lifespan via attenuation of TOR/S6K-driven translational output. The model correctly identifies the TOR/nutrient sensing axis as the key pathway, and appropriately generalizes from known ribosomal protein deletion studies. The confidence level of 0.72 is reasonable given the gene-specific uncertainty. Overall, this is a high-quality prediction with correct answer and correct mechanistic reasoning.",
  "failure_mode": "correct",
  "answer_correct": true,
  "mechanism_correct": true,
  "reasoning_quality": 5,
  "ground_truth_questionable": false
}