egl-27
C. elegans
Egg-laying defective protein 27;GATA-type domain-containing protein
What the model saw
Gene: egl-27 Organism: Caenorhabditis elegans Known functions: Egg-laying defective protein 27;GATA-type domain-containing protein. RNA polymerase II-specific DNA-binding transcription factor binding. chromatin binding. enzyme binding. protein binding. sequence-specific DNA binding. transcription corepressor activity.
View unredacted entry
Egg-laying defective protein 27;GATA-type domain-containing protein. RNA polymerase II-specific DNA-binding transcription factor binding. chromatin binding. enzyme binding. protein binding. sequence-specific DNA binding. transcription corepressor activity.
Solver output
EGL-27 is a GATA-type domain-containing transcription corepressor that binds chromatin and interacts with RNA Pol II machinery, functioning as part of the NuRD/MEC complex in C. elegans. As a transcription corepressor with chromatin-binding activity, EGL-27 participates in epigenetic regulation of gene expression programs. In C. elegans, the NuRD complex (which includes EGL-27/MTA homologs) has been linked to repression of stress-response and developmental genes; corepressor complexes that maintain chromatin organization and repress pro-aging transcriptional programs (e.g., suppressing hyperactivation of stress or inflammatory pathways) tend to support longevity. The GATA-type domain further suggests involvement in regulating developmental and metabolic transcriptional networks relevant to lifespan. However, the specific longevity targets of EGL-27 corepression are not fully defined, introducing some uncertainty.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted pro_longevity for egl-27. The mechanistic reasoning is plausible and well-grounded - EGL-27 is indeed a MTA (metastasis-associated) homolog that functions in the NuRD complex as a transcription corepressor with chromatin-binding activity. The model correctly identifies the epigenetic/chromatin remodeling mechanism and connects it to longevity through repression of pro-aging transcriptional programs. Confidence of 0.55 is appropriately modest given the indirect nature of the reasoning. The reasoning is solid but somewhat speculative about specific longevity targets, which the model itself acknowledges.
Raw API responses
solver
{
"reasoning": "EGL-27 is a GATA-type domain-containing transcription corepressor that binds chromatin and interacts with RNA Pol II machinery, functioning as part of the NuRD/MEC complex in C. elegans. As a transcription corepressor with chromatin-binding activity, EGL-27 participates in epigenetic regulation of gene expression programs. In C. elegans, the NuRD complex (which includes EGL-27/MTA homologs) has been linked to repression of stress-response and developmental genes; corepressor complexes that maintain chromatin organization and repress pro-aging transcriptional programs (e.g., suppressing hyperactivation of stress or inflammatory pathways) tend to support longevity. The GATA-type domain further suggests involvement in regulating developmental and metabolic transcriptional networks relevant to lifespan. However, the specific longevity targets of EGL-27 corepression are not fully defined, introducing some uncertainty.",
"confidence": 0.55,
"key_pathways": [
"NuRD/MEC chromatin remodeling complex",
"GATA transcription factor regulatory network",
"RNA Pol II transcriptional corepression"
],
"mechanism_class": "epigenetic_alterations",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model correctly predicted pro_longevity for egl-27. The mechanistic reasoning is plausible and well-grounded - EGL-27 is indeed a MTA (metastasis-associated) homolog that functions in the NuRD complex as a transcription corepressor with chromatin-binding activity. The model correctly identifies the epigenetic/chromatin remodeling mechanism and connects it to longevity through repression of pro-aging transcriptional programs. Confidence of 0.55 is appropriately modest given the indirect nature of the reasoning. The reasoning is solid but somewhat speculative about specific longevity targets, which the model itself acknowledges.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 4,
"ground_truth_questionable": false
}